Ultrasonic characterization of porcine liver tissue at frequency between 25 to 55 MHz

AIM： To study the relation between acoustic parameters and histological structure of biological tissue and to provide the basis for high-resolution image of biological tissues and quantitative ultrasonic diagnosis of liver disease. METHODS： Ultrasonic imaging and tissue characterization of four normal porcine liver and five cirrhotic liver tissue samples were performed using a high frequency imaging system. RESULTS： The acoustic parameters of cirrhotic liver tissue were larger than those of normal liver tissue. The sound velocity was 1577 m/s in normal liver tissue and 1631 m/s in cirrhotic liver tissue. At 35 MHz, the attenuation coefficient was 3.0 dB/mm in normal liver tissue and 4.1 dB/mm in cirrhotic liver tissue. The backscatter coefficient was 0.00431 dB/Srmm in cirrhotic liver tissue and 0.00303 dB/Srmm in normal liver tissue. The backscatter coefficient increased with the frequency. The high frequency images coincided with their histological features. CONCLUSION： The acoustic parameters, especially the sound backscatter coefficient, are sensitive to the changes of liver tissues and can be used to differentiate between the normal and pathological liver tissues. High frequency image system is a useful device for highresolution image and tissue characterization.

瞄准：学习在声学的参数和生物织物的组织学的结构之间的关系并且为生物纸巾的高分辨率的图象和肝疾病的量的超声的诊断提供基础。方法：超声的成像和四个正常的猪的肝和五件硬变肝织物样品的织物描述用一个高频率成像系统被执行。结果：硬变肝织物的声学的参数比正常的肝织物的那些大。健全速度在硬变肝织物是在正常的肝织物和 1631 m/s 的 1577 m/s。在 35 MHz，变细系数在硬变肝织物是在正常的肝织物和 4.1 dB/mm 的 3.0 dB/mm。反散射系数在正常的肝织物是在硬变肝织物和 0.00303 dB/Srmm 的 0.00431 dB/Srmm。反散射系数与频率增加了。与他们的组织学的特征与一致的高频率图象。结论：声学的参数，特别健全反散射系数，对肝纸巾的变化敏感并且能习惯于在正常、病理学的肝纸巾之间的 differentiate。高频率图象系统是为高分辨率的图象和织物描述的一台有用设备。