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大连地区汉族人BβFg基因启动子区-455G/A多态性分析 被引量：1

The Study on the Promoter Region ofβ-fibrinogen Gene Polymorphisms in Dalian Chinese
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摘要 目的观察我国北方汉族人β纤维蛋白原(BβFg)基因启动子区-455G/A多态性特点。方法应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法测定153名大1连地区汉族人BβFg基因启动子区-455G/A等位基因及基因型。结果G-455等位基因频率为0.781,A-455等位基因频率为0.219,基因型GG、GA、AA的频率分别为0.588、0.386、0.026。结论大连地区汉族人群βFg基因-455G/A多态的等位基因及基因型频率与南方汉族人有差别,但与欧美白种人群相近。 Objective To analyze the frequency of beta- fibrinogen gene -455G/A polymorphisms in Han nationality in Dalian Chinese and explore its characteristic in Han nationality in North China. Methods The beta-fibrinogen gene -455G/A polymorphisms for 153 individuals were analyzed by polymerase chain reaction-restrictive fragment length polymorphism （PCR-RFLP）. Results The frequencies of A^-455 , G^-455 allele were 0. 219 and 0. 781, respectively; and the frequencies of the genotype GG, GA, AA were 0. 588, 0.386, and 0.026, respectively. Conclusion The frequency of BβFg A455 allele in Han national population was consistent with Cauasians in Europe and America.
作者 卞秋武 林海龙 张静 徐鹤 唐学杰 王庆胜 柳东田 郭子江 姚福梅 郭春蕾
机构地区 河北医科大学附属秦皇岛市第一医院心内科 大连大学附属大连市中心医院心内科 大连医科大学附属二院 盘锦市第一人民医院 大连市第二人民医院心内科 大连市辛寨子地区医院内科
出处 《中国分子心脏病学杂志》 CAS 2005年第4期588-591,共4页 Molecular Cardiology of China
关键词 Β纤维蛋白原 基因多态性 汉族人 基因启动子区-455G/A Beta-fibrinogen Gene polymorphism Chinese
分类号 Q987 [生物学—遗传学]
  • 相关文献

参考文献17

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二级参考文献16

  • 1[1]Weng X, Cloutier G, Genest J Jr. Contribution of the455G/A polymorphism at the [beta] -fibrinogen gene to erythrocyte aggregation in patients with coronary artery disease [J].Thromb Haemost. 1999; 82: 1406-1411.
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共引文献54

同被引文献6

  • 1梁亮,孙川,肖锋,汤小兰,陈晓丹,周代锋,王小英,王政,刘国勋,程爽,凌光鑫,包承鑫,蔡望伟.海南汉族人群九个纤维蛋白原基因多态性及其与血浆纤维蛋白原水平的关系[J].中华医学遗传学杂志,2005,22(4):457-461. 被引量：20
  • 2Leander K,Wiman B,Hallqvist J,et al.The G-455A polymorphism of the fibrinogen Bbeta-gene relates to plasma fibrinogen in male cases,but does not interact with environmental factors in causing myocardial infarction in either men or women[J].Intem Med,2002,252:332-341.
  • 3David C,Sane MD,Scott A,et al.Frequency of aspirin resistance in patients with congestive heart failure treated with antecedent aspirin[J].AM J Cardiol,2002,90:893-895.
  • 4Feng D,Lindpaintner K,Larson MG,et al.Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism:the Framingham Offspring Study[J].Arterioscler Thromb Vasc Biol,1999,19:1142-1147.
  • 5Feng D,Lindpaintner K,Larson MG,et al.Platelet glycoprotein Ⅲa Pl(a) polymorphism,fibrinogen,and platelet aggregability:The Framingham Heart Study[J].Circulation,2001,10,104:140-144.
  • 6马丽媛,赵勇,王兴宇,刘一仙,刘力生,Klaus Lindpaintner.纤维蛋白原基因G(-455)A多态性与缺血性脑卒中的关系[J].中华老年心脑血管病杂志,2001,3(2):96-98. 被引量：16

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二级引证文献6

中国分子心脏病学杂志
2005年 第4期

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