基因GADD45-β在肥厚型心肌病发病机制中的潜在作用浅谈
The Potential Role of GADD45-β Gene in the Development of Hypertrophic Cardiomyopathy
摘要
GADD45-β是GADD45家族中的一员,属于核内蛋白,主要通过调控p38和JNK来抑制细胞生长及细胞凋亡过程的。细胞核因子NF-kB是GADD45-β的上游调节因子,它对GADD45-β的调节有多种方式,但是最终都落到调节细胞生长及凋亡过程上来。目前关于GADD45-β的研究主要集中在肿瘤、癌症方面,有很多涉及GADD45-β的文献主要是研究它在肿瘤、癌症方面的功能。
出处
《中国分子心脏病学杂志》
CAS
2005年第4期616-618,共3页
Molecular Cardiology of China
参考文献18
-
1[1]Zhang W, Bae I, Krishnaraju K, et al. CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene, 1999, 18 (35) :4899-4907.
-
2[2]Selvakumaran M, Lin HK, Sjin RT, et al. The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells. Mol Cell Biol, 1994, 14(4) :2352-2360.
-
3[3]Balliet AG, Hatton KS, Hoffman B, et al. Comparative analysis of the genetic structure and chromosomal location of the murine MyD118(Gadd45beta) gene. DNA Cell Biol, 2001, 20(4):239-247.
-
4[4]Zhang W, Hoffman B, Liebermann DA. Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis. Int J Oncol,2001, 18(4) :749-757.
-
5[5]Koonin EV. Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins.J Mol Med, 1997, 75(4) :236-238
-
6[6]Jin R, De Smaele E, Zazzeroni F, et al. Regulation of the gadd45beta promoter by NF-kappaB. DNA Cell Biol, 2002, 21(7) :491-503.
-
7[7]Qiu W, David D, Zhou B, et al. Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. Am J Pathol, 2003, 162 (6) :1961-1974.
-
8[8]Arimoto T, Katagiri T, Oda K, et al. Genome-wide cDNA microarray analysis of gene-expression profiles involved in ovarian endometriosis. Int J Oncol, 2003, 22(3): 551-560.
-
9[9]Thyss R, Virolle V, Imbert V, et al. NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J, 2005, 12; 24(1): 128-137.
-
10[10]Hu Y, Sun H, Drake J, Kittrell F, et al. From mice to humans: identification of commonly deregulated genes in mammary cancer via comparative SAGE studies. Cancer Res, 2004, 1; 64(21 ): 7748-7755.
-
1黄仕和,秦椿华.转化生长因子β的研究现状[J].生理科学进展,1991,22(2):131-135.
-
2江岩,伊德林,霍艳.小鼠视交叉上核内c-fos基因蛋白水平的检测方法及其分析[J].沈阳医学院学报,2005,7(1):44-44. 被引量:1
-
3郑霞.胰岛素样生长因子-1与高血压[J].心血管病学进展,2003,24(3):205-207. 被引量:1
-
4甘欣锦,孔祥蕾,徐旻,沈伟.特发性血小板减少性紫癜患者血清转化生长因子β_1水平的研究[J].山西医药杂志(下半月),2011,40(11):1118-1118. 被引量:1
-
5戴冽,汤美安,尹培达.转化生长因子β与类风湿性关节炎[J].国外医学(内科学分册),1999,26(5):214-217. 被引量:9
-
6李冬梅,汪伟,黄可欣,马洪喜.口服低剂量硝酸镧对糖尿病大鼠心肌NF-κB和TNF-α表达的影响[J].中国免疫学杂志,2013,29(9):948-951.
-
7白爱平,欧阳钦,甘华田,王春晖.肿瘤坏死因子︿对肠上皮细胞核因子B的活化与细胞因子表达的影响[J].四川大学学报(医学版),2004,35(6):778-780. 被引量:2
-
8宋灿,黄亚男,霍海如,谭余庆.转化生长因子β对血管重塑的调节作用[J].国际药学研究杂志,2012,39(5):405-408. 被引量:3
-
9何顺华,李冠武,黄宁宇.白藜芦醇诱导HL-60细胞凋亡机制的实验研究[J].癌变.畸变.突变,2009,21(2):109-113. 被引量:1
-
10张传山,杨舒婷,毕晓娟,李亮,吕国栋,林仁勇.泡型包虫病患者肝脏组织TGF-β1和Gadd45γ基因的表达及其在肝损伤中的作用研究[J].中国病原生物学杂志,2016,11(10):908-912. 被引量:9