基因GADD45-β在肥厚型心肌病发病机制中的潜在作用浅谈
The Potential Role of GADD45-β Gene in the Development of Hypertrophic Cardiomyopathy
摘要
GADD45-β是GADD45家族中的一员,属于核内蛋白,主要通过调控p38和JNK来抑制细胞生长及细胞凋亡过程的。细胞核因子NF-kB是GADD45-β的上游调节因子,它对GADD45-β的调节有多种方式,但是最终都落到调节细胞生长及凋亡过程上来。目前关于GADD45-β的研究主要集中在肿瘤、癌症方面,有很多涉及GADD45-β的文献主要是研究它在肿瘤、癌症方面的功能。
出处
《中国分子心脏病学杂志》
CAS
2005年第4期616-618,共3页
Molecular Cardiology of China
参考文献18
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