一氧化氮合成酶抑制剂在急性心肌梗死心原性休克中的应用进展
Development of Nitric Oxide Synthase Inhibitor Applications in the Treatment of Cardiogenic Shock after Acute Myocardial Infarction
摘要
急性心肌梗死合并心原性休克死亡率高,预后差。即使在升压药物治疗的基础上,给予经皮主动脉气囊反搏、早期血运重建和机械通气等措施后,一定程度上降低了死亡率,但效果仍不容乐观。一氧化氮合成酶(NOS)抑制剂作为一种新的治疗心原性休克的药物,具有升高血压、改善冠脉灌注,降低一氧化氮(NO)对心肌的毒性和提高心肌细胞对儿茶酚胺类物质的反应性等作用。对血管重建术后仍顽固的心原性休克疗效显著,降低死亡率,改善预后。
出处
《中国分子心脏病学杂志》
CAS
2005年第1期434-436,共3页
Molecular Cardiology of China
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