卵巢囊腺癌术后血清CA125回落幅度与DNA指数的关系

Relationship between postoperative decline of serum CA125 level and DNA index in ovarian cystadenoma

【目的】探讨卵巢囊腺癌术后CA125回落幅度是否与DNA指数有关。【方法】将42例该病患者依据术后图像分析仪测定的DNA指数分成两组:≤1.4组和>1.4组。收集术前和术后第20天的血样本,测定血清CA125水平,进行相关分析。【结果】DNA指数≤1.4组的血清CA125回落幅度明显强于DNA指数>1.4组(P<0.05)。当术前CA125水平300 U/ml以上时,术后CA125水平在DNA指数≤1.4组明显低于>1.4组,差异有显著性意义(P<0.05)。【结论】卵巢囊腺癌术后CA125回落幅度可能与DNA指数有关。

Abstract： [Objective] To correlate the postoperative decline of serum CA125 level with the DNA index in patients with ovarian eystadenoma. [Methods] The cellular DNA index of tumor cells from the samples of 42 patients with the disease was measured by computerized image analysis. Patients were divided into two groups： DNA index≤1.4 and DNA index 〉 1.4. The samples were collected preoperatively and 20 days after operation. Serum CA125 were determined by radioimmunoassay. [Results] The postoperative decline of serum CA 125 was significantly higher in group of DNA index≤ 1.4, （ P 〈 0.02）. When preoperative serum CA125 above 300 U/ml, patients with D NA index ≤ 1.4 had a lower level of postoperative serum CA125 （ P 〈 0.05）. [Condusion] The postoperative decline of serum CA125 level may be correlated with DNA index.