胆石形成早期胃肠移行性复合运动变化的实验研究

Experimental study on the changes of gastrointestinal MMC during the early stage of cholesterol gallstone formation

【目的】探讨胆固醇结石形成早期胃肠移行性复合运动(MMC)变化。【方法】用45只豚鼠做实验,在胃窦、十二指肠和空肠浆膜埋植银丝电极,记录MMC。【结果】随着1%高胆固醇饲料喂养时间的延长,胃肠MMC周期、Ⅱ相时程逐渐延长,Ⅲ相时程逐渐缩短。【结论】胆固醇结石形成早期,消化间期MMC周期延长,Ⅱ相时程延长,Ⅲ相时程缩短。

[Objective] To determine the changes of gastrointestinal migrating motor complex （MMC） during the early stage of cholesterol gallstone formation. [Methods] Records of gastrointestinal M MC of 45 healthy adult guinea pigs were studied. [Results] The MMC cycle duration and the duration of phase Ⅱ were prolonged significantly and gradually compared with that of the control group （ P 〈 0.01 ） and the duration of phase Ⅲ was significantly and gradually shorter than that of the control group when received a 1% （high） cholesterol diet. [ Conclusion] During the early stage of cholesterol gallstone formation the MMC cycle and the duration of phase Ⅱ are prolonged and the duration of phase Ⅲ is shortened.