白细胞介素1受体拮抗基因多态性与骨质疏松症的相关性

The relationship between interleukin-1 receptor antagonist protein gene polymorphism and osteoporosis in postmenopausal women

目的了解广东地区汉族人群中白细胞介素-1受体拮抗基因(IL-1ra)基因型的分布,探讨IL-1ra基因多态性与骨质疏松症的关系。方法应用PCR及电泳检测等技术,对广东地区汉族人群中IL-1ra基因型的分布及其与骨质疏松症的易感性进行分析。结果在广东人群中IL-1ra基因多态性与骨质密度紧密相关性,骨质疏松组和健康对照组在IL-1ra等位基因性的分布上有明显差异。结论本研究人群中IL-1ra基因型可能作为预测骨质疏松发生的危险性指标。

Objective To investigate the distribution of IL- 1ra genotypes among the Hans Nationality in Guangdong Province and analyze the relationship between IL- 1ra gene polymorphism and osteoporosis. Methods Hart Nationality women were divided into observation and control groups and IL- 1ra genotypes were determined by polymerase chain reaction followed by eleetrophoresis on agarose gel. The distribution of IL- lra genotypes was analyzed among the Hans Hationality women in Guangdong. Results Significantly differences in the distribution of alleles or genotypes were observed between groups. Conclusion Polymorphism of IL - 1ra gene is correlated with osteoporosis in Han Nationality women in Guangdong Province, The IL- 1ra genotype can be used as risk indicator in predicting the occurrence of osteoporosis.