参麦加味汤对新生大鼠缺氧缺血性脑病脑组织LA、脑含水量影响的实验研究

Experimental study of effects of Shenmai Jiawei Decoction on levels of lactic acid, water content in brain tissue of hypoxic-ischemic encephalopathy in neonate rats

目的:通过参麦加味汤对新生大鼠缺氧缺血性脑病脑乳酸、脑含水量的影响,探讨参麦加味汤对脑保护的作用机理。方法:将32只大鼠随机分为假手术组、模型组、参麦组、丹参组,分别对各组大鼠脑组织乳酸含量、脑含水量进行检测。结果:与假手术组比较,模型组大鼠脑组织乳酸含量、脑含水量显著升高(P<0.05)。与模型组比较,参麦组、丹参组可显著降低脑组织乳酸含量(P<0.01)、脑含水量(P<0.05)。结论:参麦加味汤具有调节脑细胞乳酸代谢、缓解酸中毒和减轻脑水肿、保护脑细胞的作用。

Objective： Through study effect of Shenmai Jiawei Decoction （SMJW） on levels of lactic acid （LA） ,water content in brain tissue of hypoxic-ischemic encephalopathy in neonate rats, to research the mechanism of SMJW＇s protective function. Methods：32 rats were divided into 4 groups randomly：sham operated group, model group, SMJW group and Danshen group. Then observed the effect of SMJW on levels of LA, water content in brain tissue. Results： LA, water content in model group was much higher than those of sham operated group（P 〈 0.05）. Compared with model group, SMJW could not only obviously decrease LA content （P 〈 0.01）,but also significantly decrease water content （P 〈 0.05） in brain tissue of neonate rats. Conclusion： SMJW has functions of adjusting the LA metabolism, releasing acidosis and cerebral edema of brain tissue.