nm23和p53蛋白在喉鳞癌组织中表达的意义

Expression of nm23 and p53 Protein in Laryngeal Squamous Cell Carcinoma and It's Neighboring Dysplastie Tissue

应用免疫织化技术，检测了32例喉鳞癌组织及12例癌旁异型增生组织的nm23和p53蛋白的表达情况。结果发现：nm23与p53在喉鳞癌组织的阳性表达率分别是87．50％及84．38％。在癌旁异型增生组织阳性表达率分别为100％和20％。nm23的表达与喉鳞癌的组织学分级有关，p53的表达与喉鳞癌组织学分级无关，但p53的强阳性表达预示预后不良。

We detected the expression of nm23 and p53 protein in tissue of 32 cases of laryngeal squamous cell carcinoma and l2 cases of dysplastic tissue surrounding the cancer by bounohistochemistry techniques. The results indicated: the positivity rate of nm23 and p53 expression in laryngeal squamous cell carcinoma was 87.50%and 84.38% respectively. The positivity rate of heterotype tissue surrounding the tumor was 100% and 20%, respectively. There was sighficant correlation between positive expression of nm23 and degree of differentiation of laryngeal squamous cell cercinoma, There was no significant correlation between positive expression of p53 protein and degree of differentiation of laryngeal squamous cell carcinoma. In addition, strong positive expression of p53 protein was predicted with poor prognosis.