异丙酚复合氯胺酮微量泵输注在小儿麻醉中的应用

The application of propofol-ketamine combination microinjection pump to children intravenous anesthesia

目的对比观察异丙酚复合氯胺酮微量泵输注给药和间断分次静脉给药用于小儿麻醉的临床效果。方法选择小儿手术麻醉60例,随机分为A、B两组,每组30例。A组采用异丙酚氯胺酮复合液(每100mg异丙酚+100mg氯胺酮)微量泵持续输入法麻醉,B组采用间断分次静脉注入氯胺酮的方法麻醉。记录两组手术时间、异丙酚和氯胺酮的各自用量,观察术前、切皮时、探查时、缝合时的心率(HR)、血压(BP)、血氧饱和度(SpO2)的变化,手术过程中的不良反应及苏醒时间。结果A组异丙酚和氯胺酮每公斤体重的平均用量明显少于B组(P<0.05)。术中心率、血压的变化B组较A组明显(P<0.05),术中不良反应B组多于A组(P<0.05)。结论异丙酚氯胺酮复合微量泵输注给药用于小儿麻醉安全有效、调控方便迅速、可控性强、麻醉过程平稳、不良反应少,优于间断分次给药的方法。

Objective To compare the effection of child propofol-ketamine combination microinjection pump intravenously anesthesia with interval intravenously added propofol-ketamine anesthesia. Methods Sixty child were randomly divided into groud A （propofol-ketamine combination microinjection pump intravenous anesthesia, n = 30） and group B（interval intravenous added propofol-ketamine combination anes- thesia, n = 30）.The operating time and the dose of propofol and ketamine of two groups were reconted respectivdy.The change of HR, BP, SpO2 before operation and during skin incision,exploration and skin sutures after medicine,and the side effect during operation and recovery time were observed.Result The doses of group A were less than those of group B（P 〈 0.05） .The changes of HR,BP,SpO2 during operation in group A were obvionsly than in group B（P 〈 0.05） and there was less side effect in group A. Conclusion Propofol-ketamine combination mien）injection pump intravonous anesthesia in children is a safty, effective and convenient method and it is better than the method of interval intravenously added propofol-ketamine combination anosthesia.