C-erbB-2在甲状腺癌中的表达及意义

Expression and clinical significance of C-erbB-2 in thyroid carcinomas

目的探讨C-erbB-2在甲状腺癌中的表达及其临床意义。方法应用免疫组化SP法对30例甲状腺癌组织和20例甲状腺良性病变组织中C-erb-B2的表达进行检测。结果C-erb-B2在甲状腺腺瘤、结节性甲状腺肿、甲状腺癌、有淋巴结转移的甲状腺癌、无淋巴结转移的甲状腺癌中的表达率分别为0%、0%、66.7%、83.3%、41.7%;甲状腺良性病变与甲状腺癌两者相比差异有高度显著性(P<0.001),有淋巴结转移者的阳性率明显高于无转移者(P<0.05)。结论CerbB2的检测对甲状腺良恶性肿瘤的鉴别诊断具有参考价值,CerbB2可以作为判断甲状腺癌生物学行为的重要指标。

Objective To detect the expression and clinical significance of C-erbB-2 in thyroid carcincmas.Methods The expresaion of C-erbB-2 was examined by S-P immunohistochemical technique method in 30cases of thyroid carcinomas and 20 casses of thyriod berign disease .Resuits Positive expression rates of C-erbB-2 protein in thyroid adenomas, nodular goitre, thyroid carcinoma, thyrioid carinoma with lymphatic metastaais, thyroid carcinoma without lymphatic metastasis were 0%,0%,66.7%,83.3%,41.7% respectively.The compariaon between thyroid berign disease and throid carcinoma showed statistically significant difference（P〈0.001）,the positive rate in thyroid carcinoma with lymphatic metastasis was statistically higher than that without lymphatic metastasis（P〈0.05）. Conclusion The data suggest that the examination of C-erbB-2 is of value in differential diagnosis of berign of malignant thyroid diseaae lesiona, C-arbB-2 may be used as an imporant marker for the asscassment of biological behavior of thyroid carcinoma.