摘要
目的比较两种老年人常见的皮肤肿瘤—鳞状细胞癌(BCC)与基底细胞癌(SCC)的生物学行为的异同。方法用免疫组化方法检测了26例SCC、30例BCC及10例正常皮肤组织中桥粒芯糖蛋白1(Dsg1)和E-钙黏着蛋白(E-cad)的表达。结果Dsg1在BCC和SCC中的表达均显著减弱或完全消失;E-cad在SCC中的表达显著减弱,而在BCC中的表达却为阳性。结论BCC和SCC侵袭性生长的特性与Dsg1的低表达有关,SCC易发生转移的特性与E-cad的低表达有关。
Objective To evaluate the difference of the clinical, biological and histopathological features in two kinds of elders, skin careinoma BCC and SCC. Methods We investigated desmogleinl and E - cadherin expression in 26 SCC and 30 BCC with monoclonal antibod- ies to desmogleinl and E - cadherin used immunohistochemistry staining. Results In SCC the expression of desmogleinl and E - eadherin markedly reduced or absent in tumor ceils. In BCC the expression of desmogleinl markedly reduced or absent in trmor ceils also, but E - cad- herin was strongly expressed. Conclusion These results suggest the reduction or absence of desmogleinl expression may be related to invasiveness of skin carcinomas, the reduction or absence of E - cadherin expression may be related to the metastasis of SCC.
出处
《宁夏医学杂志》
CAS
2006年第5期362-363,共2页
Ningxia Medical Journal
