环鸟苷酸对卵巢细胞功能的调控

Regulation of Ovarian Function by cGMP

环鸟苷酸(cGMP)是一种具有广泛生物学活性的环核苷酸。尽管cGMP作为第二信使,在调控卵巢细胞功能中发挥着广泛而重要的作用早有报道,但直至近年,cGMP在生殖活动中的重要作用才受到人们的关注,而成为生殖科学研究领域的热点之一。卵巢是雌性动物的重要器官,而cGMP在卵巢细胞中起着多方面的调节作用。现对卵巢内cGMP的来源,cGMP在卵巢内抑制雌激素(E2)的合成、LH受体表达、卵泡闭锁的作用,以及cGMP的作用机制等方面的研究进展进行综述。

Cyclic guanosine monophosphate （cGMP） as one kind of cyclic nucleotides, plays important roles in various physiological processes. It was known that cGMP, as a second messenger, had a potential role in modulating ovarian functions in 1980s. However, the role of cGMP modulating ovarian functions has received considerably less attention. Ovary is an important organ in the female animal, and cGMP regulates a wide range of ovarian functions. This report reviews the production of cGMP, the inhibitory effect of cGMP on ovarian estradiol production, LH receptor expression and follicular atresia, and the mechanism of cGMP signalling.