乳腺癌组织中p53、nm23-H1基因表达及其与绝经状态、淋巴结转移的相关性

Expression of p53 and nm23-H1 in the Tissues of Breast Cancer and Its Correlation with Menopausal Status and Lymphatic Metastasis

[目的]研究乳腺癌患者中p53和nm23-H1基因表达,及其与绝经状态及腋窝淋巴结转移的关系。[方法]采用免疫组织化学SP方法检测60例乳腺癌组织中p53和nm23-H1的表达。[结果]60例乳腺癌患者中,p53和nm23-H1的阳性表达率分别为73.3%(44/60)和66.7%(40/60);在绝经前患者中p53和nm23-H1的阳性表达率分别为66.7%(16/24)和50.0%(12/24),而在绝经后患者中两者的阳性表达率分别为77.8%(28/36)和77.8%(28/36)。在绝经后患者中p53和nm23-H1基因的阳性表达与腋窝淋巴转移呈显著性相关(P=0.019和P=0.019)。[结论]p53可能参与绝经前妇女乳腺癌的发生,可能促进绝经后乳腺癌的转移;而nm23-H1可能参与绝经后乳腺癌的转移。

[Purpose ] To study the role of expression of p53 and nm23-H1 in lymphatic metastasis of breast cancer, and the correlation between expression of p53 and nm23-H1. [Methods] Expression of p53 and nm23-H1 in 60 patients with breast cancer was dctcetcd by immunohistoehemieal S-P method. [Results] Of 60 eases with breast cancer, 44 cases （73.3%） and 40 cases （66.7%） were positive tor p53 and nm23-H1 protein respectively. In premenopausal patients with breast cancer, expression of p53 and nm23-H1 was 66.7% and 50.0% respectively, and in postmenopansal that was 77.8% and 77,8% respectively. In postmenopausal patients with breast cancer, expression of p53 and nm23-Hl was related to lymphatic metastasis（P=0.019 and P=0.019）, [Conclusion] p53 may play an role in the earcinogenesis of breast cancer in premenopausal patients by the regulation of endocrine system, and could promote lymphatic metastasis in postmenopausal breast cancer patients, nm23-H1 gene may take part in lymphatic metastasis in postmenopausal breast cancer patients.