低剂量氟尿嘧啶持续输注联合奥沙利铂治疗老年晚期胃肠道恶性肿瘤

Combined Continuous Infusion Fluorouracil with Low-dose and Oxaliplatin in Treatment for Senile Advanced Gastrointestinal Cancer

[目的]观察低剂量氟尿嘧啶(5-Fu)持续输注联合奥沙利铂(L-OHP)方案治疗老年性晚期胃肠道恶性肿瘤的近期疗效及毒副反应等。[方法]32例晚期胃肠道恶性肿瘤患者给予5-Fu225mg/(m2·d)微量泵持续静脉滴注3周,L-OHP60mg/m2d1、8、15,静脉滴注,28d为1个周期,2个周期后评定疗效。[结果]CR1例,PR14例,NC13例,PD4例,32例病例的总有效率为46.88%(15/32),其中转移性肝癌患者有效率为64.71%(11/17)。化疗后ECOG评分比化疗前有显著性改善(P<0.05)。化疗后毒副反应病人均能耐受。[结论]低剂量氟尿嘧啶持续静脉输注联合奥沙利铂方案治疗老年性晚期胃肠道恶性肿瘤是一个有效、低毒,且能显著改善生活质量的化疗方案。

[Purpose] To evaluate the short-term efficacy and toxicities of the continuous central venous infusion （e.c.v.i） Fluoronracil with low-dose and Oxaliplatin in treatment for senile advanced gastrointestinal cancer. [Methods] 5-Fu 225mg/m^2·d c.c.v.i for 3 weeks, and Oxaliplatin 60mg/m^2 intravenous drip al d1.8.15 were administered in 32 patients with advanced gastrointestinal carcinoma. The regflnen was repeated every 28 days. The assessment was carried out after two cycles, [Results] One patient achieved complete response; 14, partial responses; 13, no change; and 4, progressive disease. The overall response rate was 46.88%（15/ 32）. The response rate was 64.71% （11/17） in patient with liver metastasis. The score of ECOG was significantly improved than that before ehemotherapy（P〈0.05）. The toxicities of chemotherapy were well tolerated. [Conclusions] Combined chemotherapy of continuous infusion 5-Fu with low-dose and Oxaliplatin in an effeetive, less toxicity regimen which can and improve the quality of life quality in senile advanced gastrointestinal cancer.