摘要
合成了M eso-5,10,15,20-四(对羟基苯基)卟啉(H2THPP)和M eso-5,10,15,20-四(对氨基苯基)卟啉(H2TAPP),分别将其与Cu(AC)2、Mn(AC)2、Fe(AC)2和Co(AC)2通过固相反应和柱层析分离得到它们的金属配合物。将金属配合物与NO反应合成了金属卟啉-NO配合物,并通过FT-IR1、H NMR、元素分析和MS测试技术对上述配合物的结构进行表征。在室温下采用重氮化和偶合反应研究了这些金属卟啉-NO配合物在水溶液中NO的释放效果,发现THPP-Co-NO、THPP-Fe-NO、TNPP-Co-No和TNPP-Fe-No配合物均具有较好的释放效率,分别为59.48%、66.42%、63.17%和62.04%。
Meso -5,10,15,20 -tetra ( 4 -hydroxylphenyl ) porphyrin ( H2 THPP ) and meso-5,10,15,20-tetra ( 4 - aminophenyl) porphyrin( H2THPP) were synthesized with the method described in the references. The metalloporphyrin complexes were prepared via the solid-state reactions of the porphyrins with Cu (Ac) 2, Mn ( Ac ) 2, Fe( Ac)2 or Co( Ac)2 and purified by using column chromatography, and the correspending nitrosyl metalloporphyrin complexes were synthesized by combining the metalloprphyrin complexes with nitric oxide. The structures of the above synthetic products were characterized by means of FT-IR, ^1H NMR, MS and elemental analysis. The NO-releasing properties of the nitrosyl metalloporphyrins in aqueous solutions were studied by diazotization at room temperature. The results show that NO-releasing efficiencies of THPP-Co-NO, THPP-Fe- NO, TNPP-Co-NO and TNPP-Fe-NO were 59. 48%, 66.42%, 63. 17% and 62. 04% respectively.
出处
《应用化学》
CAS
CSCD
北大核心
2006年第5期508-513,共6页
Chinese Journal of Applied Chemistry
基金
湖北省科技攻关重点项目(20002P0325)
湖北省自然科学基金资助项目(2005ABA173)
关键词
金属卟啉
NO载体
合成
体外释NO作用
metalloporphyrin, nitric oxide carrier, synthesis, NO-releasing in vitro