2-硝基-4-氯-2′-羟基-3′-特丁基-5′-甲基偶氮苯的固相合成

Solid Phase Synthesis of 2-Nitro-4-chloro-2′-hydroxy-3′-t-butyl-5′-methyl-azobenzene

在室温下,以对氯邻硝基苯胺邻叔丁基对甲基苯酚和亚硝酸钠为原料通过固相重氮偶合反应一步合成了2-硝基-4-氯-2′-羟基-3′-特丁基-5′-甲基偶氮苯。反应时间15 m in,产率达93%。以HPLC分析,其纯度>99%,并用IR和UV光谱等对其结构进行了表征和确认。

2-Nitro-4-chloro-2′-hydroxy-3′-t-butyl-5′-methyl-azobenzene was synthesized via diazo coupling reaction in solid phase with 4-chlor-2-nitroaniline, 2-t-butyl-4-methyl phenol and sodium nitrite at room temperature. The reaction was completed through one-step method within 15min in a yield of 93% with a higher than 99% purity（by HPLC）, and the structure of the compound was comfirmed by IR and UV.