期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

星形细胞肿瘤组织MMP-2与TIMP-1、TIMP-2的表达 被引量：5

EXPRESSION OF MATRIX METALLOPROTEINASE-2,TISSUE INHIBITOR OF METALLOPROTEINASE-1 AND TISSUE INHIBITOR OF METALLOPROTEINASE-2 IN ASTROCYTOMA
下载PDF
导出
摘要 目的探讨基质金属蛋白酶MMP-2和金属蛋白酶抑制剂TIMP-1、TIMP-2在人脑星形细胞肿瘤组织中的表达及其与肿瘤临床生物学行为的关系.方法采用免疫组织化学SP法检测52例星形细胞肿瘤组织中MMP-2、TIMP-1和TIMP-2的表达情况.结果 MMP-2、TIMP-1、TIMP-2在星形细胞瘤（WHO Ⅱ级）、间变性星形细胞瘤（WHO Ⅲ级）与胶质母细胞瘤（WHO Ⅳ级）中的表达水平,差别具有统计学意义（Hc=7.966～10.353,P〈0.05）.结论 MMP-2、TIMP-1和TIMP-2在星形细胞肿瘤组织中的表达与星形细胞肿瘤的侵袭性生物学行为的演进密切相关. Objective To study the expressions of matrix metalloproteinase-2 （MMP-2）, tissue inhibitor of metalloproteinase-1 （TIMP-1） and tissue inhibitor of metalloproteinas-2 （TIMP-2） in astrocytoma and their relationship with the clinical biological behavior of the tumor. Methods Expressions of MMP-2, TIMP-1 and TIMP-2 were detected in 52 cases of astrocytoma by immunohistochemical （SP） staining method. Results The differences of the expressions of MMP-2, TIMP-1 and TIMP-2 in astrocytoma （WHO grade Ⅱ ）, anaplantie astrocytoma （WHO grade Ⅲ） and glioblastoma （WHO grade Ⅳ） were significant （ Hc= 7. 966- 10. 353,P〈0.05）. Conclusion The expression of MMP-2, TIMP-1 and TIMP-2 are closely correlated with the development of the invasive activity of human astrocytoma.
作者 聂文洁 迟菁华 纪祥瑞 王良忠
机构地区 青岛万杰医院病理科 青岛大学医学院病理学教研室
出处 《齐鲁医学杂志》 2006年第2期101-102,105,共3页 Medical Journal of Qilu
关键词 基质金属蛋白酶 金属蛋白酶类组织抑制剂 胶质瘤 免疫组织化学 metalloproteinase tissue inhibitor of metalloproteinase glioma immunohistochemistry
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1KLAUS L,UWE M,MRCIA R,et al.Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors[J].Am J Pathol,1998,153:429.
  • 2FORSYTH P A,WONG H,LAING T D,et al.Gelatinase A(MMP-2),gelatinase-B(MMP-9)and membrane type matrix metalloproteinase-1(MT-MMP) are involved in different aspects of the pathophysiology of malifnant gliomas[J].Br J Cancer,1999,79(11/12):1828.
  • 3MOHANAM S,WANG S W,RAYFORD A,et al.Expression of tissue inhibitors of metalloproteinases:negative regulators of human glioblastoma invasion in vivo[J].Clin Exp Metastasis,1995,13(1):57.
  • 4MOHANAM S,WANG W W,RAYFORD A,et al.Expression of tissue inhibitors of metalloproteinases:negative regulators of human glioblastoma invasion in vivo[J].Clin Exp Metastasis,1995,13:57.
  • 5NAKANO A,TANI E,MIYAZAKI K,et al.Matrix metalloproteinases and tissue inhibitors of metalloproteases in human gliomas[J].J Neurosurg,1995,83:208.
  • 6NUTTALL R K,PENNINGTON C J,TAPLIN J,et al.Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells[J].Mol Cancer Res,2003,1(5):333.
  • 7HERRON G S,WERB Z,DWYER K,et al.Secretion of metalloproteinases by stimulated capillary endothelial cells.Ⅰ.Production of procollagenase and prostromelysin exceeds expression of proteolytic activity[J].Biol Chem,1986,261:2810.
  • 8KACHRA Z,BEAULIEU E,DELBECCHI L,et al.Expression of matrix metalloproteinases and their inhibitors in human brain tumors[J].Clin Exp Metastasis,1999,17(7):555.

同被引文献32

  • 1张采欣,纪祥瑞,张景芳,郝风云.Cathepsin-D、MMP-2和MMP-9在乳癌组织中的表达[J].齐鲁医学杂志,2005,20(3):219-221. 被引量：4
  • 2温洋,戴建平,高培毅,李少武,孙学进.ASL在胶质瘤分级中的初步应用[J].中国医学影像技术,2005,21(9):1371-1375. 被引量：17
  • 3范丽,陶晓峰,刘士远,施增儒,肖湘生.ASL在中枢神经系统疾病诊断中的初步应用体会[J].放射学实践,2007,22(7):675-678. 被引量：21
  • 4Kohn EC,Liotta IrA. Molecular insights into cancer invasion: strategies for prevention and interventi [J]. Cancer Res, 1995,55 (9) : 1856-1862.
  • 5Michael M, Babic B, Khokha R, et al. Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small--cell lung cancer[J]. J Clin Oncol, 1999,17(16) : 1802-1808.
  • 6Zhao Y, I.yons CE Jr, Xiao A,et. Urokinase directly activates matrix metaltoproteinases--9: a potential role in glioblastoma invasion [J]. Biochem Biophys Res Corn mun,2008,369(4) : 1215-1220.
  • 7Ivaska J, Heino J. Adhension receptors and cell invasion:mechnasim of integrin--guided degredation of extracellar matrix[J]. Cell Mol Life Sci,2000,57(1):16-24.
  • 8Grignon DJ, Sakr W, Toth M, el al. High level of tissue inhibitor of metalloproteinase-- 2 (TIMP-- 2) expression associated with poor outcome in invasive bladder cancer[J]. Cancer Res, 1999,56(7):1654-1659.
  • 9Nakanoa,Tanie,Miyaza, et al . Matrix metalloproteinases and tissue inhibitors of metalloproteases in human gliomas[J]. J Neurosurg, 1995,183:208.
  • 10Aaberg--Jessen C, Christensen K, Offenberg H, et al. Low expression of tissue inhibitor of metalloproteinases --1 (TIMP--1) in glioblastoma predicts longer patient survival[J] J Neurooncol, 2009,95 ( 1 ) : 117 - 128.

引证文献5

二级引证文献24

齐鲁医学杂志
2006年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部