脑利尿钠肽与早期糖尿病肾病的关系

RELATIONSHIP BETWEEN SERUM BRAIN NATRIURETIC PEPTIDE AND EARLY-STAGE DIABETIC NEPHROPATHY

目的探讨血清脑利尿钠肽（BNP）与早期糖尿病肾病（DN）的关系及其临床意义.方法随机选择非肥胖2型糖尿病病人64例,按尿微量清蛋白排泄率（UAER）分为早期DN组（DN＋组,UAER 20～200 μg/min,30例）和非DN组（DN-组,UAER〈20 μg/min,34例）;健康成人30例作为对照（CON）组.应用酶联免疫吸附法（ELISA）测定各组血清BNP水平.结果 DN-组血清BNP的水平明显高于CON组（F=6.82, q=4.30, P〈0.01）,DN＋组血清BNP的水平高于DN-组（q=4.80, P〈0.01）;且与UAER呈明显的正相关（r=0.85,P〈0.01）.结论早期DN病人血清BNP水平显著升高, 可能在DN的发生、发展过程中起重要作用.

Objective To investigate the relationship between the serum brain natriuretic peptide （BNP） and early-stage diabetic nephropathy, and to analyze its clinical significance. Methods Sixty-four patients with nonobese type 2 diabetes mellitus and 30 normal controls were studied. According to urinary albumin excretion rate （UAER）, the 64 patients were divided into two groups, one with microalbuminuria （DN＋） and the other with normoalbuminuria （DN 5. The serum levels of BNP were measured with competitive Enzyme lmmunoassay kit. Results The serum levels of BNP were significantly higher （F= 6.82, q= 4.30, P〈0.01） in all the patients than those of normal subjects. The blood concentrations of BNP were significantly increased with microalbuminuria, compared with those with normoalbuminuria （F=6. 82, q=4, 80, P〈0.015, The serum levels of BNP were positively and significantly correlated with UAER （r=0.85, P〈0.01） in diabetic nephropathy. Conclusion The serum levels of BNP were significantly increased in patients with early-stage diabetic nephropathy, which probably play an important role in the occurrence and development of this disease.