摘要
目的研究同种异体脂肪组织提取液对大鼠皮肤创面愈合的影响.方法 18只大鼠随机分成3组,在每只大鼠背部制备2个全层皮肤缺损创面,脂肪组织提取液组用同种异体脂肪组织提取液0.2 mL,基质对照组用磷酸盐缓冲液（PBS）0.2 mL,分别滴于创面,每天1次;空白对照组不滴加任何制剂.采用创面面积、伤腔容积和组织学指标评价创面愈合效果.结果伤后7 d脂肪组织提取液组创面面积和伤腔容积均明显小于基质对照组和空白对照组（F=105.51、8.67,q=4.29～18.71,P〈0.05）.组织学检查显示脂肪组织提取液组创面肉芽组织和新生表皮生长明显.伤后14 d脂肪组织提取液组创面愈合情况优于基质对照组和空白对照组（F=96.47,q=17.73、16.82,P〈0.05）.结论同种异体脂肪组织提取液可加快大鼠皮肤创面愈合的速度,改善愈合质量.
Objective To explore the effects of homologous adipose tissue extracts on wound healing after skin injury in rats. Methods Eighteen Wistar rats were randomly divided into three groups, namely adipose tissue extracts-treated group, PBS control group, and blank control group. Full-thickness wounds were made on the back of the rats （two wounds for each rat） followed by the above treatment once a day. Wound areas and volumes, as well as histology marker were used to evaluate the effects on wound healing. Results At day 7 after injuries, the areas and the volumes of injuries in the extracts-treated group were decreased significantly compared with those in the two control groups （F=105.51,8.67;q =4.29=18.71：P〈0.05）, while granulation tissue and nascent epidermis grew more obviously in the extracts-treated group than those in the two control groups （F=96.47;q=17.73,16.82;P〈0.05）. At day 14 after injuries, the wound healing in the extracts-treated group was superior to the other two. Conclusion Homologous adipose tissue extracts can accelerate velocity and improve the quality of wound healing after skin injury in rats.
出处
《青岛大学医学院学报》
CAS
2006年第2期132-134,共3页
Acta Academiae Medicinae Qingdao Universitatis
