口腔医用冰的药理作用

PHARMACOLOGICAL EFFECTS OF ORAL MEDICAL ICE

目的探讨口腔医用冰(简称口冰)的药理作用,为临床用药提供依据。方法制备二甲苯致小鼠耳部炎症、琼脂致大鼠足肿胀急性炎症模型,大鼠琼脂肉芽肿慢性炎症模型,观察口冰对炎症的作用;采用热板法进行小鼠热刺激性疼痛试验,断尾法测定小鼠出血时间,观察口冰对小鼠疼痛及出血时间的影响。结果口冰局部应用能抑制小鼠耳部肿胀、大鼠足肿胀,抑制大鼠肉芽肿,延长疼痛潜伏期,缩短小鼠出血时间。结论口冰有抗炎镇痛止血作用。

Objective To study the pharmacological effects of oral medical ice （OMI） and to provide for its evidence for clinical application. Methods The anti-inflammatory effect of OMI was determined on three inflammatory models： swelling of mice ear induced by dimethylbenzene, hind paw edema and back granuloma caused by hypodermic injection of agar in rats. The analgesic action of OMI was studied by observing the mice＇s reaction to the heat simulation. The effect of OMI on bleeding time was tested by tail-cutting method. Results OMI inhibited the swelling of mice ear, the edema of hind paws and the chronic subcutaneous granuloma formation. OMI also prolonged latency of pain and significantly shortened the bleeding time. Conclusion OMI has anti inflammatory, analgesic and hemostatic effects.