泊尼松治疗24例丛集性头痛的疗效观察

Therapeutic effect of predisone in the treatment of 24 patients with episodic cluster headache

目的探索泊尼松治疗丛集性头痛的有效性。方法采用前瞻性的方法,给予丛集性头痛患者口服泊尼松40mg/d,连服10 d,然后每周减10 mg,与既往发作的丛集期比较,观察患者的丛集发作时间、发作频率、疼痛程度。结果经泊尼松治疗后丛集性发作时间较前有缩短[(2．88±1．23) d vs (28.88±11．96)d],有显著性差异(P=0．000);头痛发作频率较前有减少[(1．04±2．42)d vs (15．50± 11．24)d],有显著性差异(P=0．000);头痛的程度较前减轻[(0．83±1．74)d vs (9．83±0．48)d],有显著性差异 (P=0．000)。结论泊尼松能非常有效治疗丛集性头痛发作。

Objective To study the effectiveness of predisone in preventing cluster headache. Methods 24 patients with episodic cluster headache were treated with prednisone （40 mg/day, orally） for 10 consecutive days, followed by gradual decrease of the dosage （10 mg/week）. Headache parameters （duration of active phase, onset frequency and degree of pains） at the active phases treated with prednisone were compared with those of previous active phases in the same patients treated with other prophylactic medications. Results Compared with previous treatment by predisone, the duration of active phases, onset frequency and degree of pains were significantly decreased （2.88 ± 1.23） d vs （28.88 ± 11.96） d, P= 0.000;（1.04±2.42 ） d vs （15.50±11.24） d, P=0.000; （0.83±1.74） d vs （9.83±0.48） d, P=0.000, respectively）. Conclusion Prednisone is effective in reducing duration of cluster, frequency and severity of headache in patients with episodic cluster headache.