结直肠癌免疫治疗

Immunotherapy of Colorectal Cancer

目的探讨结直肠癌免疫治疗的现状与研究进展。方法采用文献回顾的方法对结直肠癌免疫治疗现状及其研究进展进行综述。结果结直肠癌免疫治疗的研究内容及主要方法包括:主动非特异性免疫治疗、过继免疫治疗、单克隆抗体(mAb)治疗、主动特异性免疫治疗、导向治疗等。结论免疫治疗为手术和放(或)化疗的有益补充治疗,在结直肠癌综合治疗中发挥着重要的辅助作用。

Objective To generally analyze the current situations and advancement of the study on immunotherapy for colorectal cancer. Methods The pertinent published papers about the current situation and research advancement of the immunotherapy of colorectal cancer were retrospectively investigated. And also the immunogenicity and the varying principles of immunoresistance, the functional targets, the practicality, and some other characteristics of different immunotherapy for colorectal cancer were reviewed. Results The main treatments and the research focuses in the immunotherapy of colorectal cancer are initiative nonspecific immunotherapy, adoptive immunotherapy, monoclonal antibody immunotherapy, initiative specific immunotherapy, and targeted therapy. They work by fighting against the cancer itself, cutting off the tumor＇s nutrition supply, activating the immune system specifically or breaking the immune tolerance and so on. Though there are still many problems unsolved, immunotherapy has a promising clinical prospect. Conclusion As a beneficial complement for surgery, chemotherapy and radiotherapy, immunotherapy plays an important auxiliary role in the combined therapy for colorectal cancer.