摘要
目的:探讨P27蛋白(P27)和增殖细胞核抗原(PCNA)在原发性胆囊癌中的表达和意义。方法:应用免疫组化SP法检测40例胆囊癌组织中P27和PCNA蛋白的表达,分析其表达的意义和相关性。结果:PCNA阳性率为55.0%(22/40),P27阳性表达率为42.5%(17/40),两者与患者的年龄和性别均无相关性(P>0.05),与淋巴结转移有关(P<0.05),与组织学分级有关(P<0.05),PCNA和P27在胆囊癌中的表达无相关性(P>0.05)。结论:胆囊癌组织中PCNA和P27的表达可能是反映胆囊癌生物学行为和预测预后的重要指标。
Objective: To investigate correlation of the expression of P27 and PCNA and the clinicobiological behaviors in human gallbladder carcinoma tissues. Methods: The expression of P27 and PCNA in 40 cases of human gallbladder carcinoma were detected with immunohistochemistry of SP. Results: The positive expression rate of PCNA and P27 was 55.0%(22/40) and 42.5%(17/ 40) respectively. Both of the two targets' rate had no relationship with patients" age and gender (all P〉0.05), but they all related with lymph-node metastasis and pathological grading (all P〈 0.05). The expression of PCNA in gallbladder carcinoma had no relationship with the expression of P27 (P〉0.05). Conclusion: The expression of P27 and PCNA may be regarded as an important marker in biological characters and prognosis of gallbladder carcinoma.
出处
《武汉大学学报(医学版)》
CAS
2006年第3期361-362,374,i0003,共4页
Medical Journal of Wuhan University