银杏叶片对地方性砷中毒患者七项肝功能指标的影响

The Influence of Ginkgo Leaf on Hepatic Function of Patients Endemic Arsenism

背景与目的:探讨银杏叶片对地方性砷中毒(地砷病)患者七项肝功能指标的影响并初步分析其作用机制。材料与方法:用生化法测定银杏叶片治疗前后地砷病患者血清中七项肝功能指标。结果:银杏治疗前患者血清总蛋白(Totalprotein,TP)、白蛋白(Albumin,ALB)含量及胆碱脂酶(Cholineesterase,CHE)活性均显著低于正常对照组(P<0.01),γ-谷氨酰转肽酶(γ-glutamyltranspeptidase,γ-GT)活性则明显高于正常对照组(P<0.01);丙氨酸氨基转移酶(Glutamicpyruvictransaminase,ALT)、总胆红素(Totalbiliribin,TBil)及直接胆红素(conjugatedbiliribin,DBil)差异无统计学意义(P>0.05)。银杏治疗后患者血清中的TP、ALB含量及CHE活性较治疗前显著升高,γ-GT活性则明显降低(P<0.01);ALT、TBil及DBil3项指标在治疗前后未见明显变化(P>0.05)。结论:银杏叶片对地砷病患者肝功能的损害有一定的改善作用;TP、ALB、CHE和γ-GT4项指标在砷致肝损害的诊断及疗效观察中有一定的参考价值;银杏叶片改善地砷病患者肝功能的作用机制可能与其促进肝细胞修复、抑制脂质过氧化过程和保护肝合成功能等有关。

BACKGROUND ＆ AIM：To explore the influence and the mechanism of Ginkgo leaf tablet on hepatic function of patients with endemic arsenism.MATERIAL AND METHODS：Biochemical methods were used to measure the levels of seven hepatic biochemical markers of patients with arsenism before and after treatment. RESULTS： Comparied with the normal control group, sefium total protein （TP） and albumin（ALB）, choline esterase（CHE） levels were significantly lower, γ- glutamyl transpeptidase（γ- GT） was obviously higher（P 〈0.01） in the patients before treatment.Glutamic pyruvic transaminase（ALT）, total biliribin（TBil） and conjugated biliribin（DBil） didn＇t show evident changes （P 〉 0.05） . After treatment, the levels of TP, ALB and CHE significantly increased, whilst γ-GT obviously decreased （P 〈0.01）. ALT, TBil and DBil didn＇t show obvious changes（P 〉 0.05）. CONCLUSION： Ginkgo leaf had certain effects in improving arsenism patients＇ hepatic function. TP, ALB, CHE and γ-GT were useful markers value in the diagnosis and monitoring treatment. The mechanisms of Ginkgo leaf may be related to promoting liver cell repair, anti-oxidative damage and protecting hepatie synthetic function.