未负载种植体骨界面形态与元素动态改变相关实验研究

The Research on Correlation Between the Dynamic Changes of Elements and the Shape of the Interface in Unloaded Implants

观察种植界面微区元素改变与种植界面形成的关系。建立并采用种植体动物模型,应用X线观察,组织学观察,扫描电镜观察以及电子探针X射线能谱分析方法对界面进行研究。X线平片,组织学观察及扫描电镜观察表明12周时,种植体界面已形成大量新生骨组织。钛合金种植体植入后,12周内,钙元素与磷元素逐渐增加并达到峰值,以后趋于平稳,钛元素含量在植入后2周较高,以后逐渐减少。种植体与机体组织之间只有极薄的一层纤维膜,已达到骨结合标准。钙元素与磷元素在骨结合界面形成过程中起主导作用,本研究使用的钛合金种植体在实验条件下植入后,短期内会释放游离离子,但不足以影响骨结合界面的形成。

To investigate the relationship between the element changes of interface mieroregion and the formation of implant interface. X plain films , histologic microscope , scan electronic microscope and electronic probe X - ray mierorcgion analysis were used in this study. Resuhs showed that 12 weeks after the implantation , a large amount of new bone formation was observed in the X plain films , histologic microscope and scan electronic microscope. The percentage of Ca and P elements inereased slowly and reached the peak in 12 weeks, then changed to be steady and persisted with the time. The percentage of Ti reached the peak in 2 weeks after implantation and decreased with the time. Ca and P is the important elements in the formation of bone--implant interface. Ti6A14V alloy implants will release some free Ti ion to the tissues, but it can not influence the formation of bone interface.