放射性核素电子计算机断层摄影测量左室心肌质量与儿童青少年血压关系的研究

The Study of the Relationship between Left Ventricular Mass Measured by ECT and Blood pressure in Children and Adolescents

高血压合并左心室肥厚早已被人熟知。近年来研究发现左室心肌质量的增加伴随着血压明显增高达９０百分位或以上在儿童时期即已出现。一般认为左室心肌质量的增加是高血压或血压偏高的结果。仅在最近几年才有少数作者发现左室心肌质量的增加出现在儿童发生血压增高之前。血压正常儿童或青少年之父母有高血压者，其左室心肌质量均高于无高血压家族史者。本研究者在观察血压增高与高血压家族史及左室心肌质量之间的关系时，结果发现在高血压高危儿童并有家族史者左室心肌质量高于高血压高危儿童无高血压家族史者，提示除血压增高可能为左室心肌质量增加之原因外，而且左室心肌质量之增加尚可能为高血压之原因，即有可能在先天因素中存在左室心肌质量易于增加的因子或者说不能除外心室肌异常基因的存在。

It is well known that hypertension may complicate with left ventricular hypertrophy;Research in recent years has disclosed that the increase of left ventricular mass(LVM)accompanying blood pressure level equal to/or higher than 90th percentile may appear during childhood. Generally the increase of LVM is the result of hypertension However,it has been documented in recent years that LVM may be present before the increase of blood pressure LVM of the normotensive children or adolescents who have hypertensive parents is higher than that of normotensive children or adolescents whose parents do not have hypertension.The aim of this study is to observe the relationship between the increase of blood pressure with/without family history of hypertension and LVM.It was found that LVM of the children with a positive family history of hypertension is greater than that of the children with a negative family history.This shows that hypertension may cause the increase of the LVM and vice versa,It is suggested that a congenital factor favoring the increase of LVM is present.We speculate that this factor might be an abnormal gene responsible for the development of increase of LVM and the emerge of hypertension.