沈阳市非吸烟女性肺癌危险因素的病例对照研究

Case-control Study on Risk Factors Associated with Lung Cancer among Non-smoking Women in ShenyangWang

于１９９１年４月至１９９４年１２月在沈阳市区内进行了对终身非吸烟女性肺癌危险因素调查的病例对照研究，共选调了新诊断的非吸烟原发性肺癌病例１６６例及相应数量、配比年龄与性别的一般人群为对照，病理组织细胞型以腺癌为主．占６２．２％．其次为小细胞癌．占１７．１％，鳞癌占１４．６％，其他为６．１％，用Ｍｅｎｔａｌ－Ｈａｅｎｓｘｌ法与多因素Ｌｏｇｉｓｔｉｃ回归模型对资料进行分析，其调整ＯＲ与９５％Ｃｌ值：烹饪油烟暴露为４．１１（２．１４～７．８９）．肺部疾病史为２．９８（１．３０～６．４１），亲属患病史为２．９８（１．３０～６．４１），煤烟在单因素分析中对肺癌发生有显著意义．但未进入多因素分析模型。被动吸烟与烧炕史诸因素均未见与肺癌的发生有联系．

The importance of risk factors for lung cancer in lifetime nonsmoking women was investigated in a case-control study in the urban area of Shenyang between April of 1991 and December of 1994. One hundrend and sixty six newly diagnosed lung cancer cases and an equal number of controls matched for age and sex.were enrolled and interviewed by trained porsonals who administrated a standardized questionnaire. The histopat hological cell type was dominated by adenocarcinoma(62.2%).followed by small cell type carcinoma(20.0%),squamous cell carcinoma(14.6%),and othets(6.1%).The date were analyzed by using the Mental-Haenszel method and by multivariate logistic regression analysis.The odds ratio and confidence interval associated with cooking oil vapors.previous lung diseasex and with family history of cancer were 4.11(95 %Cl.2.14～7.89).2.05(95%CI 1.08～3.93)and 2.98(95%CI,1.30～6.41).respectively.No association was found between exposute to Passive smoking and other varibales.