前列腺素E1对腹部手术后行持续硬膜外镇痛胃肠功能恢复的临床观察

The Influences of PGE1 injection on intestinal function recovery in patients under- going abdominal urgery and postoperative analgesia

目的:研究前列腺素E1(prostaglandin E1,PGE 1)对腹部手术后使用术后镇痛泵肠功能恢复的影响。方法:82例腹部手术患者,随机分为两组:前列腺素E1组(41例),手术第1日起连用3 d 前列腺素E1,术毕接镇痛泵;对照组(41例)除未用前列腺素E1外,余步骤均相同。结果:前列腺素E1组患者术毕肛门排气时间、拔胃管时间、进流质时间均提前13-16 h,较对照组有显著性差异(P<0．01)。结论:腹部手术患者使用前列腺素E1,可明显促进胃肠功能的正常恢复。

Objective： To investigate the role of prostaglandin E1 （PGE1） injection on intestinal function recovery in patients undergoing abdominal surgery and postoperative analgesia. Methods： 82 cases of the patients undergoing abdominal surgery were divided into control group and PGE1 group randomly. PGE1 group was treated with prostaglandin E1 by intravenous injection for 3 days and used analgesia pump as the same time after the operation. The control group was treated as the same process with equal volume of normal saline instead of PGE1. Anus exhaust time,removing stomach tube time and intake time of liquid diet were observed. Results： The all above time in PGE1 group was significantly shorter than those in control group （P〈0.01）. Conclusion： PGE1 injection can obviously promote the intestinal function recovery in patients undergoing abdominal surgery and postoperative analgesia.