流体切应力对血管内皮细胞基因表达的影响

Effect of flow shear stress on the genes expression of vascular endothelial cells

血液产生的切应力可以引起血管中的内皮细胞发生生物物理、生化和基因调控水平上的反应,从而调节内皮的结构和功能。当内皮细胞受到的切应力发生变化时,即可引起细胞基因表达上的变化,从而可能引发一些常见的心血管疾病。对切应力调控内皮细胞基因表达机制的研究,有助于找到治疗以上疾病的临床方法。综述了切应力对内皮细胞基因表达的影响及其调控机制,并对其在临床治疗、小口径人工血管构建和药物设计等方面的应用前景进行了展望。

Blood shear stress can induce the changes of biophysical, biochemical features and gene expression of the vessel endothelial cells, consequently modulate the structure and function of the endothelium. When the shear stress acted on the endothelial cells changes, gene expression of the cells would be induced. And some ordinary cardiovascular diseases might be aroused as a result. The research on the modulating mechanism of the shear stress on gene expression of the endothelial cells might be helpful to find the clinical ways to cure those diseases. The influence and the modulating mechanism on gene expression of the endothelial cells are reviewed in this article. The prospect of the applications in clinics, in construction of the small artificial blood vessels and the design of drugs are reviewed.