413例甲型副伤寒临床特征及药敏分析

Clinical features and drug sensitive test of 413 cases with paratyphoid A

目的分析413例甲型副伤寒的临床特点及药物敏感情况。方法对413例甲型副伤寒病例回顾性分析。结果有地方性和散发性,全年发病夏秋季多发,常以发热(100%)、头痛(98.5%)、咽痛(30.75%)、咳嗽(23.5%)及脾肿大(78%)、周围嗜酸性粒细胞消失(98.75%)为特点。细菌对奈啶酸、诺氟沙星、妥布霉素,庆大霉素等的耐药性发生率大于60%。结论该市近年散发流行的甲型副伤寒沙门氏菌感染,症状不典型,常以发热、头痛、咽痛、咳嗽及脾肿大、周围嗜酸性粒细胞消失为特点,细菌对喹诺酮类药物高度耐药。

[Objective] To analyse the clinical features and the results of sensitive test against antibiotics of paratyphoid A. [Methods] 413 cases of paratyphoid A were studied by retrospective analysis. [Results] Paratyphoid A was epidemic obviously in summer and autumn in the local area. The symptoms were fever （100%）, headache（98.5%）, pharynx pain（30.75%）, cough （23.5%）, spleen enlargement（78%） and no eosinophil in blood （98.75%）.The results of drug reactive tests showed that the drug rate of the bacteria against Nalidixic acid, Norfloxacin, Tobramycin and Gentamycin was more than 60%. [Conclusion] Paratyphoid A was occasional epidemic in the last years in our city, and the patient with the disease had no typical symptoms. The obvious symptoms were fever, headache, pharynx pain, cough, spleen enlargement and no eosinophil in blood. The highly drug resistance rate of appeared that it was the most resistive rate of the quinolones to paratyphoid A was observed.