甲状腺肿瘤细胞DNA含量分析

FLOW CYTOMETRIC DNA CONTENT ANALYSIS IN THYROID NEOPLASMS

本文应用流式细胞术对６６例甲状腺肿瘤进行了ＤＮＡ含量分析。结果表明２６例甲状腺腺癌中，１１例为ＤＮＡ异倍体，１２例为近二倍体；不同类型的甲状腺癌之间，ＤＮＡ含量无统计学差异，但ＤＮＡ合量与组织学分化程度密切相关。４０例甲状腺腺瘤中，仅２例为ＤＮＡ异倍体，与甲状腺球癌相比，甲状腺癌的异倍体率明显升高（Ｐ＜０．０１）；且２例经重新复习切片，１例被确诊为滤泡性癌，另１例伴有不典型增生。因此，流式分析ＤＮＡ含量对良、恶性的鉴别具有重要价值。

DNA content in 66 paraffin embedded thyroid tumors(26 adenocarcinomas and 40 adenomas)were analysed by flow cytometry.The results showed that 11 of 26 carcinomas were aneuploidy and DNA content was not significant difference in different histological types,but it was closely related to the degree of malignancy.In the 40 cases of adenomas,only 2 were aneuploidy.The sections were reviewed,one was thyroid follicular carcinoma,the another was adenoma with dysplasia.The findings indicate the DNA aneuploidy is a possible aid in the often difficult histopathologic distinction of thyroid follicular carcinomas from adenomas.