急性白血病合并DIC53例临床分析

Clinical Investigation of 53 Cases with Acute Leukemia Associated Disseminated Intravascular Coagulation

对53例AL合并DIC作回顾分析。并发DIC的AL类型为APL 28例,非M_3型ANLL 15例、ALL 10例,发生于AL初发期、诱导化疗和化疗间歇期、难治期的DIC分别占25、11、17例。结果显示,APL合并DIC 68%发生于初发期,非M_3期ANLL并DIC发生于难治期占60%,而ALL并DIC 50%与诱导化疗有关。40例经全程治疗者,DIC治愈8例,其中6例为初发期患者（6/16）。讨论了DIC发生与患者白细胞数、感染、化疗等因素的关系。认为系统总结AL合并DIC临床特点,有助于认识及防治该并发症。

This paper presented retrospective investigations of 53 cases with acute leukemia (AL) associated disseminated intravascular coagulation (DIG). Objects included 28 patients with acute promyelocytic leukemia (APL) 15 cases with acute nonlymphoblastic leukemia excluded APL (Non-M3-ANLL) and 10 with acute lym-phoblastic leukemia (ALL). In 53 cases,there were 25,11 and 17 patients with DICwhich occurred respectively at presentation, during and after remission induction,at the refractory stage of the disease. Among patients with APL,DIC was found in 68% at presentation. DIC associated with Non-M3-ANLL was detected in 60% at the refractory stage,and an half ALL-associated DIC related to induction chemotherapy. 8 patients with DIC were cured in all 40 who recieved systemic treatment. DIC at presentation of AL was cured in 6/16. Relationships of DIC with infection, chemotherapy and number of leucocytes were discussed. It conclued that this kind of investigation is useful in prevention and treatment of DIC associated with AL.