硒与端粒酶

Telomerase and Selenium

硒是人体必需微量元素,它参与抗氧化酶谷胱甘肽过氧化物酶和多种硒蛋白的组成,在体内发挥消除自由基、抗氧化物等作用。硒的抗衰老与抑制肿瘤细胞生长的作用是通过它对端粒酶的作用而实现的。研究端粒酶的调控及其与细胞凋亡的关系已成为人类种瘤研究的新热点。

Selenium is a necessary trace element of human body. It participates to make up antioxidase （such as glutathione peroxidase） and many other selenium proteins that exert the effects in eliminating free radical and antioxidation in human body. The effects of selenium in resisting senescence and inhibiting tumorous cellular growths are accomplished through its effects on cellular telomerase. It has become a new hot point of human oncology research to study the relationship of regulation on the telomerase activity with the cellular apoptosis.