硫酸氢钠催化合成水杨酸乙酯

Preparation of ethyl salicylate catalyzed by sodium hydrogen sulfate

以硫酸氢钠为催化剂合成水杨酸乙酯.考察醇酸物质的量比、催化剂用量、反应时间以及反应温度对酯化率的影响.结果表明,硫酸氢钠的催化活性较高,在最佳条件下合成水杨酸乙酯,酯化率可达80.1%～88.2%.实验结果得到的最佳实验条件为：催化用量2 g,n（乙醇）：n（水杨酸）=10：1,反应时间6 h,反应温度75～80℃.

Ethyl salicylate was prepared using sodium hydrogen sulfate as the catalyst. Influences of n （alcohol） ： n （ salicylic acid）, catalyst dosage, reaction time and reaction temperature were investigated. The results showed that the sodium hydrogen sulfate exhibited higher catalytic activity. Esterification efficiency of 80.1%--88.2 % was obtained under optimum condition as follows： catalyst dosage 2 g, n （alcohol） ： n （salicylic acid） = 10：1, reaction time 6 h, reaction temperature 75 - 85 ℃.