米索前列醇辅助治疗剖宫产重度产后出血的临床观察

目的观察米索前列醇治疗剖宫产重度产后出血的临床效果。方法对我院1997年1月～2004年12月分娩的34例重度产后出血进行回顾性分析。所有病例均予以米索前列醇舌下含服,在胎儿娩出吸尽宫腔内羊水后立即给予米索前列醇200μg,每隔4～6小时再含服,总量600μg。观察产后米索前列醇的作用、用药前后血压变化及用药后出现的副作用。结果32例重度产后出血用药后有效,米索前列醇用药前后血压无显著性差异(P﹥0.05)。结论米索前列醇促进子宫收缩作用明显,是一种简单、安全、有效的治疗重度产后出血方法。

Objective：The aim of this study was to observe the effects of misoprostol in treatment of severe postpartum haemorrhage （severe PPH） in cesarean section. Methods The study consisted of 34 women who developed severe PPH after vaginal delivery and cesarean section over the eight years period January 1997 to December 2004. Severe PPH was defined as blood loss greater than 1000ml or with shock.These 34 cases of severe PPH were kept 200 u g misoprostal in mouth when the fetal is given birth and the aminiotic fluid is absorbed from the temple.The total dose of misoprostal used interval 4-6hours is 600 u g. The effect of misoprostol treatment of severe PPH,blood pressure change before/after giving misoprostol and side effects were observed. Results 32 cases of severe PPH was effective.The blood pressure change before/after misoprostol intake was not obvious （P〉0.05）. Conclusions Misoprostol has the obvious function of promoting the uterine constraction .It is a kind of simple,safe and effective method to treat severe PPH.