2－（2－甲氧基苯氧）乙胺的合成

Synthesis of 2 (2 Methoxyphenoxy)ethylamine

２－（２－甲氧基苯氧）乙胺Ⅰ是合成某些抗高血压药物的重要中间体，本研究探索二种途径制备。一是以２－甲氧基苯酚为起始原料，经相应的苯氧乙酸、苯氧乙酰胺，再用ＺｎＣｌ２－ＫＢＨ４－ＴＨＦ－Ｃ６Ｈ５－ＣＨ３体系还原，得目的物，并将Ⅰ转变成盐酸盐Ⅱ。二是通过Ｇａｂｒｉｅｌ反应制备目的物。结果表明第一种途径总收率（５８．１％）高于其他路线，并有原料易得。

Methoxyphenoxy)ethylamine Ⅰ is an important intermediate for the synthesis of some antihypertensive drugs. Two routes have been tried to obtain the product. One way was from 2 methoxyphenol Ⅲ via o alkylation, amidation and reduction by ZnCl 2 KBH 4 THF CH 3C 6H 5 system. The overall yield was 58.4%. It is an easy and economic way to prepare the compounds. Another synthetic approach was the procedure by Gabriel reaction and gave a low overall yield.