羧甲基纤维素钠颗粒的致泻作用

Purgative Effect of Sodium Carboxymethylcellulose Granules

考查了羧甲基纤维素钠颗粒对小鼠燥结型便秘、小肠推进率和炭末排出时间的药效学作用,并进行急性毒性试验。结果表明,羧甲基纤维素钠颗粒对燥结型便秘作用显著,呈明显的量效关系;对小肠推进率的作用也随剂量的增大而加强;对于炭末排出时间,仅高剂量组作用明显。以羧甲基纤维素钠颗粒分别按6.0,9.0,12.0 g/kg ig,连续观察7 d,各组均未发现死亡,小鼠ig最大耐受量>12.0 g/kg。

Sodium Carboxymethycellulose Granules(CMC-Na) is a new bulk-forming agent in domestic market. The present study examined the purgative effect of CMC-Na on the dry-form type constipation, promotion rates of small intestine and emptiness time of activated charcoal from bowel in mice. Results showed that each dose(0.2,0.4 and 1.0g/ks) of CMC-Na have increased the weight and numbers of bowel movement of dry-form type, and there are significant differences from placebo. With the doses increase, CMC-Na has enhanced the promotion rates of small intestine and the emptiness time of activated charcoal from bowel. The maximum dose for mice to be able to bear was 12.0 g/kg at least.