人体内羟基磷灰石配合自体红骨髓移植的光镜和扫描电镜观察

OBSERVATION OF IMPLANTATION OF COMBINED HYDROXYAPATITE AND AUTOGENOUS RED BONE MARROW UNDER OPTICAL AND ELECTRONIC SCANNING MICROSCOPES /

为了解羟基磷灰石（ｈｙｄｒｏｘｙａｐａｔｉｔｅ，ＨＡＰ）植入人体内的生物学行为、组织学变化以及成骨情况，对一例患胫骨纤维异样增殖症接受自体红骨髓（ｂｏｎｅ－ｍａｒｒｏｗ，ＢＭ）与ＨＡＰ复合移植的患儿，在术后１年取组织，进行了光镜及扫描电镜观察，发现：ＨＡＰ－ＢＭ周围组织未见明显炎性反应、坏死和腐蚀，ＨＡＰ基本被新生的骨组织替化，并与周围的骨组织紧密结合。结果表明，在人体内ＨＡＰ同样具有良好的生物相容性，ＨＡＰ－ＢＭ移植既能为成骨提供成骨细胞和诱骨物质，又能为骨生长提供支架。

The implantation of combined hydroxyapatite (HAP) and autogenous red bone marrow (BM) was used to repair bone defect resulting from fibrodysplasia of bone in one case. After one year, the specimen was studied under optical and electronic scanning microscopes in order to study the biological features, histological changes and osteogenesis of hydroxyapatite implanted in the body. The results showed that there was not any inflammatory, toxic, or immune reaction in the tissue surrounding HAP BM, and that HAP implanted was almost completely replaced by newly formed bone, and was firmly united to the surrounding bony tissue. This indicated that in the body HAP had a good biocompatibility and that HAP BM provided the scaffold for osseous ingrowth as well as bone induction substances. The whole result was to that of the autogenous bone graft.