氯吡格雷对非ST段抬高型急性冠脉综合征患者心脏事件的影响

Effects of clopidogrel on incidence of cardiac event in patients with acute coronary syndrome with non-ST-elevation

目的观察氯吡格雷对非ST段抬高型急性冠脉综合征患者近期心脏事件的影响。方法166例非ST段抬高型急性冠脉综合征患者分为对照组(81例)和氯吡格雷组(85例)。对照组给予常规治疗,氯吡格雷组在常规治疗的基础上即刻给予氯吡格雷300mg,随后每次75mg,每日1次,连续服14d后观察两组间复合终点事件及出血事件发生情况。结果氯吡格雷组发生9例主要心血管事件,对照组20例,显著高于氯吡格雷组(P<0.05)。两组均无主要和次要出血事件,氯吡格雷组发生轻微出血事件氯吡格雷组3例,对照组2例,两组间无显著性差异(P>0.05)。结论氯吡格雷可以降低非ST段抬高型急性冠脉综合征患者的近期心脏事件的发生率。

Objective To observe the effects of clopidogrel on incidence of cardiac event in the near future in patients with acute coronary syndrome with non - ST - elevation. Methods One hundred and sixty - six patients with non - ST - elevation acute coronary syndrome were divided into two groups： clopidogrel group （ n = 85 ） and control group （ n = 81 ）. The clopidogrel group administrated 300 nag loading dose of clopidogrel and 75 mg maintainance dose lasting for 14 days in addition to routine treatment. The control group only received routine treatment. The incidence of primary end points and bleeding episode was observed and compared. Results Primary cardiovascular event occurred in 9 cases of the clopidorel group and 20 eases in the control group（ P 〈 0.05）. There were no major and minor bleeding episodes in the two groups, Three patients and two patients with slight bleeding occurred in the clopidogrel group and the control group, respectviely, there was no obviously significant difference Conclusion Clopidogrel is effective in reducing early cardiovascular events in acute coronary syndrome patients characterized by non - ST- elevation