期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MMP-3、TGF-β_1在子宫内膜异位症中的表达及其意义 被引量：2

Expressions of MMP-3 and TGF-β_1 in endometriosis patients
下载PDF
导出
摘要 目的:探讨基质金属蛋白酶3(MMP3)和转化生长因子β1(TGFβ1)在子宫内膜异位症发生、发展中的作用。方法:采用免疫组织化学方法(SABC法)检测30例异位子宫内膜组织和30例正常子宫内膜组织(对照组)中MMP3、TGFβ1的表达情况。结果:在异位子宫内膜组织的间质细胞MMP3呈高表达状态,与正常子宫内膜相比,差异有高度显著性(P<0.01)。TGFβ1在异位子宫内膜组织的间质细胞及腺上皮细胞中均有表达,较正常对照组增强,差异有统计学意义(P<0.01)。结论:MMP3、TGFβ1在子宫内膜异位症中的表达明显高于正常子宫内膜,提示MMP3、TGFβ1可能与子宫内膜异位症发生、发展有关。 Objective ： To explore the role of matrix metalloproteinase-3 （MMP-β1） and transforming growth factor-β1 （TGF-β1） in the pathogenesis of endometriosis （ EMs ）. Methods ： Immunohistochemical method （SABC） was employed to detect the expression of MMP-3 and TGF-β1 in eetoplc endometrial tissues from women with endometriosis（30 cases） and the normal controls（30 cases） . Results ： The expressions of MMP- 3 and TGF-β1 in ectopic cndometrium with EMs were significantly high er than those of uterine endometrium from women without EMs（ P 〈 0.01）. Conclusion： The results indicate that MMP-3 and TGF-β1 might play an important role in the pathogenesis and development of endometriosis.
作者 何月 孔丽娜
机构地区 皖南医学院附属弋矶山医院妇产科
出处 《皖南医学院学报》 CAS 2006年第2期105-107,共3页 Journal of Wannan Medical College
关键词 子宫内膜异位症 MMP-3 TGF-Β1 免疫组织化学 endometriosis MMP-3 TGF-β1 immunohistochemistry
分类号 R711.71 [医药卫生—妇产科学]
  • 相关文献

参考文献6

  • 1李铁臣,孔丽娜,孙青,丁华峰,卢林明.子宫内膜异位症中MMP-2、MMP-9表达的研究[J].皖南医学院学报,2005,24(2):107-109. 被引量：6
  • 2CHILD TJ,TAN SL.Endometriosis:etiology,pathogenesis and treatment[J].Drugs,2001,61 (12):1735-1750.
  • 3SILLEM M,PRIFTI S,KOCH A,et al.Regulation of matrix metalloproteinases and their inhibitors in uterine endometrial cells of patients with and without endometriosis[J].Eur J Obstet Gynecol Reprod Biol,2001,5 (2):167-174.
  • 4RAMON L,GILABERT-ESTELLES J,CASTELLO R,et al.mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay[J].Hum Reprod,2005,20(1):272-278.
  • 5PIZZO A,SALMERI FM,ARDITA FV,et al.Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosiss[J].Gynecol Obstet Invest,2002,54 (2):82-87.
  • 6LOVERRO G,MAIORANO E,NAPOLI A,et al.Transforming growth factor-beta 1 and insulin-like growth factor-1 expression in ovarian endometriotic cysts:a preliminary study[J].International journal of molecular medicine,2001,7 (4):423-499.

二级参考文献10

  • 1Murphy AA. Clinical aspects of endometriosis[J]. Ann N Y AcadSci, 2002, 955(1): 1-10.
  • 2Ueda M, Yamashita Y, Takehara M, et al. Gene expression of adhesion molecules and matrix metalloproteinases in endometriosis[J]. Gynecol Endocrinol, 2002, 16(5):391-402.
  • 3Huang HF, Hong LH, Tan Y, et al. Matrix metalloproteinase 2 is associated with changes in steroid hormones in the aera and peritoneal fluid of patients with endometriosis [J].Fertil Steril,2004,81(5) : 1235-1239.
  • 4Collette T, BeUehumeur C, Kats R, et al. Evidence for an increased release of proteolytic activity by the eutopic endometrlal tissue in women wish endometriosis and for involvement of matrix metalloproteinase-9[J]. Hum Reprod, 2004,19(6):1257-1264.
  • 5Mori T, Yamasaki S, Masui F, et al. Suppression of the development of experimentally induced uterine adenomyosis by a novel matrix metalloproteinase inhibitor, ONO-4817, in mice[J]. Exp Biol Med (Maywood),2001,226(5) :429-433.
  • 6Osteen KG, Bruner-Tran KL, Ong D, et al. Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis[J]. Ann N Y Acad Sci, 2002,955(1):139-146.
  • 7Mulayim N, Savlu A, Guzeloglu-Kayisli O, et al. Regulation of endometrial strornal cell matrix metalloproteinase activity and invasiveness by interleukin-8[J]. Fertil Steril,2004,81(Suppl 1):904 - 911.
  • 8Cox KE, Piva M, Sharpe-Timms KL. Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions compared with endometrium[J]. Biol Reprod,2001,65(4):1297-1303.
  • 9Swiersz LM. Role of endometriosis in cancer and tumor development[J]. Ann N Y Acad Sci, 2002, 955(1): 281-292.
  • 10孙青,孔丽娜.子宫内膜异位症与肿瘤转移基因关系的研究进展[J].国外医学（遗传学分册）,2004,27(3):184-187. 被引量：16

共引文献5

同被引文献45

  • 1Schreinemacher M H,Backes W H,Slenter J M,et al.Towards endometriosis diagnosis by gadofosveset-trisodium enhanced magnetic resonance imaging[J].Plo S one,2012,7(3):33-41.
  • 2Rogers P A W,DHooghe T M,Fazleabas A,et al.Defining future directions for endometriosis research workshop report from the 2011 World Congress of endometriosis in montpellier,France[J].Reprod Sci,2013,20(5):483-499.
  • 3Liu Z,Guo B,Lopez R D.Expression of intercellular adhesion molecule(ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human gammadelta-T cells:implications in the design of gammadel-ta-T-cellbased immunotherapies for pancreatic cancer[J].J Gastroenterol Hepatol,2009,24(5):900-911.
  • 4Yin Z,Jiang G,Fung J J,et al.ICAM-1 expressed on hepatic stellate cells plays an important role in immune regulation[J].Microsurgery,2007,27(4):328-332.
  • 5Poncelet C,Leblanc M,Walke-Combrouze F,et al.Expression of cadherins and CD44 isoforms in human endometrium and peritoneal endometriosis[J].Acta Obstet Gynecol Scand,2002,81(3):195-203.
  • 6Albini A,Iwamoto Y,Kleinman H K,et al.A rapid in vitro assay for quantitating the invasive potential of tumor cells[J].Cancer Res,1987,47(12):3239-3245.
  • 7Di Carlo C,Bonifacio M,Tommaselli G A,et al.Metalloproteinases,vascular endothelial growth factor,and angiopoietin 1 and2 in eutopic and ectopicendom-etrium[J].Fertil Steril,2009,91(6):2315-2323.
  • 8Hornung D,Klingel K,Dohrn K,et al.Regulated on activation,normal T-cell-expressed and-secreted m RNA expression in normal endometrium and endometriotic implants:assessment of autocrine/paracrine regulation by in situ hybridization[J].Am J Pathol,2001,158(6):1949-1954.
  • 9Schreinemacher M H,Backes W H,Slenter J M,et al.Towards endometriosis diagnosis by gadofosveset-trisodium enhanced magnetic resonance imaging[J].Plo S one,2012,7(3):33-41.
  • 10Rogers P A W,DHooghe T M,Fazleabas A,et al.Defining future directions for endometriosis research workshop report from the 2011 World Congress of endometriosis in montpellier,France[J].Reprod Sci,2013,20(5):483-499.

引证文献2

二级引证文献5

皖南医学院学报
2006年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部