腺苷A1受体激动剂对缺血后脑组织中精氨酸加压素含量的影响

The effect of adenosine A 1, receptor angonist on concentration of AVP in cerebral iscbemic gerbils.

在沙土鼠半球缺血模型上，用放射免疫法测定了脑组织中精氨酸加压素（Ａｒｇｉｎｉｎｅｖａｓｏｐｒｅｓｉｎ，ＡＶＰ）的含量，观察了缺血后ＡＶＰ含量的变化及腺苷Ａ１受体激动剂Ｃｙｃｌｏｈｅｘｙｌａｄｅｎｏｓｉｎｅ（ＣＨＡ）对缺血后ＡＶＰ含量变化的影响。结果发现：沙土鼠缺血８ｈ后结扎侧大脑半球ＡＶＰ含量明显增加，且与卒中症状呈正相关，与脑比重呈负相关。ＣＨＡ可以改善卒中症状，减轻脑水肿，抑制缺血后ＡＶＰ的升高。提示缺血后中枢ＡＶＰ的增加将加重缺血性损伤，而腺苷对内源性ＡＶＰ系统具有抑制作用。

he concentration of arginine vasopression (AVP) was determined in gerbil cerebral cortex 8h after unilateral ligation of left common carotid artery (LCCA) by radioimmunoassay. The effect of cycolhexyladenosine (CHA),agonist of adenosine receptor A 1 on concentrations of AVP was observed. The relationships among the content of AVP and the ischemic cerebral edema as well as the stroke index were studied. It was found that the concentration of AVP was significantly increased in the hemisphere of ligated side (0.4877±0.2408 pglg wet wt, n =19, P <0 01) as compared with the ones in shamopareted animals (0.1883±0.0583, n =10) CHA significantly decreased the concentration of AVP (0.3273±0.1590, n =16, P <0.05) in the ligated animals. There was a significant positive correlation ( r =0.5395, P <0.01) between the concentration of AVP and stroke index and a significant negative correlation ( r =-0.5784, P <0.01) between the concentration of AVP and specific gravity at the ligated side. The results indicate that the neuroprotective effect of CHA on cerebral ischemia may be related to the decrease of AVP concentration.