碳酸锂对双相情感障碍的预防效果及相关因素分析

A study on prophylactic efficiency of lithium carbonate on bipolar affective disorder and relative factors.

对６４例双相情感障碍治愈出院后仍继续服用碳酸锂达３年的病人进行随访研究，结果发现碳酸锂对躁狂相的预防有效率为８１１０％，对抑郁相预防有效率为５４５０％，二者之间无显著性差异（χ２＝３．５８８，Ｐ＞００５），总预防有效率为７６５０％。在α＝０１５水平上对１２个相关因素进行多元逐步回归分析，显示预防效果与药物副作用呈负相关，而与治疗依从性、用药剂量呈正相关。

Sixty-four cases of bipolar affective disorders trea- ted with lithium carbanate were followed up for more than 3 years. It was found that total effective rate was 76.5%.Relative factors were studied with multiple regressive analysis at the 0.15000 level. These results show that the side effects have negative influence on the preventive efficiency, while daily dosage for maintenance therapy and therapentic compliance have possitive infinene on it.