Accuracy of combined PET/CT in image-guided interventions of liver lesions: An ex-vivo study

瞄准：在肝损害 interventional 设备放真希望是一项挑战性的任务 CT 是可得到的。我们在 interventional 肝研究为 interventional 设备的本地化调查了联合 PET/CT 图象的潜在的利益。方法：三十损害各个亢奋稠密， isodense 和低亚硫酸钠与正常肝实质相比的稠密的变细被注入 15 个 ex-vivo 猪肝。所有损害由包含 0.5 MBq 的胶的一样的数量组成(18 ) F-FDG。后面的损害插入，一根 interventional 针完全在 CT 指导下面被放在每损害。在那以后， PET/CT 研究被执行。在损害以内的针的本地化独自为 CT 被估计， PET/CT 和根平均数平方(RMS ) 是计算的。结果与在用作参考的标准的损害解剖以后的宏观的大小相比。结果：在低亚硫酸钠 -- 并且 isodense 损害 PET/CT 在定义 interventional 设备的位置证明更精确什么时候与 CT 相比独自一个。为 CT 和 PET/CT 的吝啬的 RMS 在 isodense 和低亚硫酸钠显著地不同稠密的损害。没有有效差量被作出对有利的裁决亢奋的稠密的损害。结论：联合 FDG-PET/CT 成像在 FDG 宠物积极的肝损害有关针位置独自比 CT 提供更精确的信息。因此联合的 PET/CT 可能为一台 interventional 设备的本地化是潜在地有益的不仅，但是可能也为在 interventional 肝的指导有益过程。

AIM： Positioning of interventional devices in liver lesions is a challenging task if only CT is available. We investigated the potential benefit of combined PET/CT images for localization of interventional devices in interventional liver studies. METHODS： Thirty lesions each of hyperdense, isodense and hypodense attenuation compared to normal liver parenchyma were injected into 15 ex-vivo pig livers. All lesions were composed of the same amounts of gelatine containing 0.5 MBq of ^18F-FDG. Following lesion insertion, an interventional needle was placed in each lesion under CT-guidance solely. After that, a PET/CT study was performed. The localization of the needle within the lesion was assessed for CT alone and PET/CT and the root mean square （RMS） was calculated. Results were compared with macroscopic measurements after lesion dissection serving as the standard of reference. RESULTS： In hypo- and isodense lesions PET/CT proved more accurate in defining the position of the interventional device when compared with CT alone. The mean RMS for CT and PET/CT differed significantly in isodense and hypodense lesions. No significant difference was found for hyperdense lesions. CONCLUSION： Combined FDG-PET/CT imaging provides more accurate information than CT alone concerning the needle position in FDG-PET positive liver lesions. Therefore combined PET/CT might be potentially beneficial not only for localization of an interventional device, but may also be beneficial for guidance in interventional liver procedures.