Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome

瞄准：与肝肺症候群在孩子在动脉的氧压力上学习口头的大蒜的效果。方法：在一种囊形式的大蒜粉末与肝肺症候群被给 15 个孩子(由对比回响心动描记法证实了) 在 1 g/1.73 m (2 ) 的剂量每天。病人们每四个星期临床上并且由动脉的血气体被评估。结果：大蒜囊与肝肺症候群予 15 个病人被以。与 9.4+/-3.9 年的吝啬的年龄有 10 个男孩和 5 个女孩。内在的问题是胆道闭锁(4 个病人) ，自体免疫的肝炎(4 个病人) ，起因不明的肝硬化(4 个病人) 和 presinusoidal 门静脉高血压(3 个病人) 。八个病人(53.3%) 在他们的吝啬的动脉的氧压力显示出 10 毫米汞柱的增加。基线 PaO (2 ) 在非应答者组是在应答者组和 47.1+/-11.2 毫米汞柱的 65.6+/-12.1 毫米汞柱。在治疗的目的，在应答者和非应答者的吝啬的 PaO (2 ) 是 92.2+/-7.75 毫米汞柱和 47.5+/-11.87 毫米汞柱，分别地(P【0.01 ) 。结论：大蒜可以增加氧化并且与肝肺症候群在孩子改进呼吸困难。

AIM： To study the effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome, METHODS： Garlic powder in a capsule form was given to 15 children with hepatopulmonary syndrome （confirmed by contrast echocardiography） at the dosage of 1 g/1.73 m^2 per day. Patients were evaluated clinically and by arterial blood gas every four weeks. RESULTS： The garlic capsule was administered to 15 patients with hepatopulmonary syndrome. There were 10 boys and 5 girls with a mean age of 9.4 ± 3.9 years. The underlying problems were biliary tract atresia （4 patients）, autoimmune hepatitis （4 patients）, cryptogenic cirrhosis （4 patients） and presinusoidal portal hypertension （3 patients）. Eight patients （53.3%） showed an increase of 10 mmHg in their mean arterial oxygen pressure. The baseline PaO2 was 65.6 ± 12.1 mmHg in the responder group and 47.1 ± 11.2 mmHg in nonresponder group. At the end of treatment the mean PaO2 in responders and non-responders was 92.2 ± 7.75 mmHg and 47.5 ± 11.87 mmHg, respectively （P 〈 0.01）. CONCLUSION： Garlic may increase oxygenation and improve dyspnea in children with hepatopulmonary syndrome.