Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India

瞄准：描述播送输送的病毒(TTV ) 的流行与在在诺思 India.METHODS 的肝疾病的不同形式的肝炎 A-E 病毒的感染联合的感染：从一个总数的血清 137 个病人数，包括 37 有尖锐病毒的肝炎( AVH )的病人，有长期的病毒的肝炎( CVH )的 37 个病人，有肝硬变的 31 个病人和有暴发性的肝的失败( FHF )的 32 个病人，为 TTV-DNA 和肝炎 A-E 病毒的标记两个都被分析。肝炎 B (HBV ) 的存在，丙肝病毒(HCV ) 和肝炎 E 病毒(HEV ) 感染在不同的组在不同比例被检测。而且， TTV-DNA 同时在 100 健康供血者 also.RESULTS 被测试：任何一个都没病人有肝炎 A 病毒(HAV ) 和肝炎 D 病毒(HDV ) 感染。TTV-DNA 的全面流行与 FHF 与 AVH，有 CVH 的 18.9% 盒子，有肝硬化的 48.4% 盒子和 9.4% 盒子在 27.1% 情况中被检测。同时在 100 健康供血者测试的 TTV-DNA 显示出 27% 确实。在与另外的肝炎建立在 TTV 感染之间的一种关系上病毒的感染， TTV 在这些疾病组与 HBV， HCV 和 HEV 表明了合作感染。有中高音的 TTV 的关联在重量的单位铺平一没在感染 TTV 的病人表明高中高音水平，建议那 TTV 不引起严重的肝 damage.CONCLUSION：TTV 感染在印度在病人和健康个人两个都是流行的。然而，它没与另外的肝炎有任何重要关联病毒的感染，它也不与肝疾病在病人生产严重的肝损坏的一条证据。

AIM： To describe the prevalence of transfusiontransmitted virus （TTV） infection in association with hepatitis A-E viral infections in different forms of liver diseases in North India. METHODS： Sera from a total number of 137 patients, including 37 patients with acute viral hepatitis （AVH）, 37 patients with chronic viral hepatitis （CVH）, 31 patients with cirrhosis of liver and 32 patients with fulminant hepatic failure （FHF）, were analyzed both for TTV-DNA and hepatitis A-E viral markers. Presence of hepatitis B virus （HBV）, hepatitis C virus （HCV） and hepatitis E virus （HEV） infections was detected in different proportions in different groups. Moreover, rrV-DNA was simultaneously tested in 100 healthy blood donors also. RESULTS： None of the patients had hepatitis A virus （HAV） and hepatitis D virus （HDV） infections. Overall prevalence of TTV-DNA was detected in 27.1% cases with AVH, 18.9% cases with CVH, 48.4% cases with cirrhosis and 9.4% cases with FHF. TTV-DNA simultaneously tested in 100 healthy blood donors showed 27% positivity. On establishing a relation between TTV infection with other hepatitis viral infections, TTV demonstrated co-infection with HBV, HCV and HEV in these disease groups. Correlation of TTV with ALT level in sera did not demonstrate high ALT level in TTV-infected patients, suggesting that TI-V does not cause severe liver damage. CONCLUSION： TTV infection is prevalent both in patients and healthy individuals in India. However, it does not have any significant correlation with other hepatitis viral infections, nor does it produce an evidence of severe liver damage in patients with liver diseases.