Effects of ranitidine for exercise induced gastric mucosal changes and bleeding

AIM： To evaluate the effect of ranitidine on gastric mucosal changes and on GI bleeding in long distance runhers. METHODS： Twenty-four long distance runners （M： 16, F： 8, age： 18.2＋ 1.5 years） participated in this study. A symptom questionnaire, stool hemoccult test, and upper gastrointestinal （GI） endoscopy were performed on the subjects prior to the study. The subjects took oral ranitidine （150 mg, b.i.d.） for two weeks. The upper GI endoscopy and stool Hemoccult tests were repeated after the treatment. RESULTS： Twenty-two of the 24 runners had at least one upper G1 mucosal lesion before the medication. The Endoscopic improvements were seen in eleven of the 14 cases of erosive gastritis and four of the 5 cases of esophagitis. Six subjects were Heine occult positive prior to the study, but only one was positive after the medication. CONCLUSION： Gastric mucosal lesions and GI bleeding in long distance runners seem to be associated to acidrelated factors mediated by the high level of regular running. Ranitidine seems to be and effective prophylaxis to prevent gastric mucosal lesions and GI bleeding.

瞄准：在胃的粘膜变化上并且在在长距离跑步者的官方补给的流血上评估 ranitidine 的效果。方法：24 个长距离跑步者(M：16， F：8，变老：18.2 +/- 1.5 年) 参予了这研究。一张症状问询表，凳子缝玄术测试，并且上面胃肠(官方补给) 内视镜检查法在学习以前在这些题目上被执行。这些题目拿了口头的 ranitidine (150 mg， b.i.d ) 为二个星期。上面的官方补给的内视镜检查法和凳子 Hemoccult 测试在治疗以后被重复。结果：24 个跑步者中的 22 个在药前有至少一上面的官方补给的粘膜损害。内视镜的改进在腐蚀胃炎的 14 个盒子中的十一个和食道炎的 5 个盒子中的四个中被看见。六个题目是在学习以前积极的血红素玄术，但是仅仅在药以后是积极的。结论：胃的粘膜损害并且在长距离跑步者的官方补给的流血似乎被联系到酸相关的因素由常规跑的高水平调停了。Ranitidine 似乎是并且阻止胃的粘膜损害并且官方补给的流血的有效预防。