胃黏膜内类癌合并印戒细胞癌伴胃壁胰腺组织异位的临床病理观察

Coexistence of carcinoid, signet-ring cell carcinoma and heterotopic pancreas in stomach: a clinicopathological observation

目的:报道胃黏膜内类癌合并印戒细胞癌和胃壁内胰腺组织异位1例,并结合文献探讨其诊断和鉴别诊断问题．方法:患者,男,63岁,主因“上腹部烧灼样不适2 a余,加重2 mo”行胃镜检查,见胃体大弯前壁黏膜结节状扁平隆起,直径0．7 cm,镜下为类癌．遂行胃大部切除,常规取材病理送检发现上述3个不同部位的病变,对此进行组织病理学、组织化学和免疫组织化学观察并复习相关文献．结果:胃体黏膜固有层内多灶内分泌细胞增生并于胃体大弯侧形成类癌,局灶浸润黏膜肌层,病变呈嗜铬颗粒蛋白A和突触素强阳性; 胃体小弯黏膜固有层内查见印戒细胞癌;胃窦小弯侧肌壁内查见异位胰腺组织伴内分泌细胞成分显著增生,后者由胰岛素、胰高血糖素、生长抑素和胃泌素阳性细胞构成．结论:胃体大弯黏膜内类癌与小弯黏膜内印戒细胞癌是各自独立的病变;肌层和浆膜层内分泌细胞团是增生的胰腺内分泌组织而非类癌浸润．

AIM： To report a case with synchronous occurrence of carcinoid, signet-ring cell carcinoma （SRC） and heterotopic pancreas in stomach. METHODS： One male patient aged 63 years old was diagnosed with coexistence of carcinoid, signet-ring cell carcinoma and heterotopic pancreas in stomach by gastroscopy and pathological examination. These three lesions were further observed by histopathological, histochemical and immunohistochemical approaches, with the related literatures reviewed.RESULTS： Multiple foci of proliferative endocrine cells were found in lanina propria of the corpus, and carcinoid was found in corpus on the greater curve of the stomach, with muscularis mucosae nvolved. The tumor cells were strongly positive for neuron-specific enolase, synaptophysin and chromogranin A. An intramucosal SRC lesion was found in the lesser curve of corpus. Heterotopic pancreatic tissue was observed in muscularis propria of the antrum on the lesser curve, with hyperplasia of endocrine cells producing multiple pancreatic hormones. CONCLUSION： Carcinoid in corpus of the greater curve and SRC in the lesser curve are independent lesions; the foci of endocrine cells in the muscularis propria and serosa are hyperplastic lesions from the heterotopic pancreatic tissue, rather than carcinoid dissemination.