盐酸二甲胺四环素治疗种植体周围炎临床效果观察

Clinical study of periocline on peri-implantitis treatment

目的探讨和评估盐酸二甲胺四环素治疗种植体周围炎的临床疗效,为其在种植体周围炎的临床应用提供初步依据。方法对30例患者种植修复0·5年以上共32枚种植体发生的种植体周围炎局部以盐酸二甲胺四环素治疗,在用药前和用药后1、3、6周检查菌斑指数(PLI)、探诊深度(PD)、龈沟出血指数(SBI),并随访半年。用SPSS10·0统计软件包配对t检验进行统计分析。结果盐酸二甲胺四环素治疗种植体周围炎后PD、SBI同用药前相比显著降低,其中无窦道型种植体周围炎药效至少能维持至停药后4周,近期治疗效果满意。结论盐酸二甲胺四环素是治疗无窦道型种植体周围炎有效的局部用药。而有窦道型种植体周围炎需结合外科手术治疗,盐酸二甲胺四环素还可作为有效的术前辅助用药控制局部炎症。

Objective To evaluate the clinical outcome and the effects of treating peri-implantitis with periocline. Methods Thirty-two sites in 32 implants with peri-implantitis were treated with periocline. The parameters including plaque index, probing depth （PD） of pocket, sulcular bleeding index （SBI） were measured at baseline, 1, 3, 6 and 12 weeks after treatment and followed up for 6 months. Results Statistically significant decrease （P 〈 0. 05 ） in SBI, and PD occurred at all time intervals compared to baseline. The treatment could last for at lest four weeks in peri-implantitis cases without fistula. Conclusions Periocline could be safely and effectively used in treating peri-implantitis in cases without peri-implant fistula. Peri-implantitis with fistula should be treated in combination with surgical methods, and periocline can also be used to control inflammation before surgery.