摘要
目的探讨C4·4A蛋白表达在鳞癌和腺癌诊断和鉴别诊断中的意义。方法应用免疫组织化学SP法检测并观察不同部位来源、不同分化程度的157例鳞状细胞癌和177例腺癌中C4·4A蛋白的表达。结果157例鳞状细胞癌中有141例C4·4A蛋白呈阳性表达,而177例腺癌中只有8例可检测C4·4A蛋白的部分或少量散在表达。鳞癌和腺癌C4·4A蛋白表达差异有统计学意义(χ2=244·93,P=0·000)。不同分化程度的鳞癌和腺癌两两比较,其C4·4A蛋白表达差异均有统计学意义(P=0·000)。结论C4·4A蛋白可作为区分鳞癌和腺癌的一个有价值的诊断标志物,有助于上皮性肿瘤的诊断及鉴别诊断。
Objective To investigate the diagnostic utility of CA. 4A gene expression in discriminating a squamous cell carcinoma （SCC） from an adenocarcinoma by immunohistochemistry. Methods Immunohistochemical staining was performed to detect the expression of CA. 4A protein in 157 cases of SCC and 177 cases of adenocarcinoma of various organs. Results Overall, 141 of 157 cases of SCC strongly expressed CA. 4A protein. In contrast, only 8 of 177 adenocarcinomas showed partial or scattered cell expression of CA. 4A protein. The statistic difference between the two groups was highly significant （X^2 =244. 93,P =0. 000）, and also when the tumors were stratified according to the degree of differentiation （P = 0. 000）. Conclusion CA. 4A protein expression may serve as a valuable tumor marker in discriminating a squamous cell carcinoma from an adenocarcinoma, and therefore, may greatly facilitate the differential diagnosis of an epithelial malignancy.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
2006年第5期277-280,共4页
Chinese Journal of Pathology
基金
广东省科技计划基金资助项目(2003A3080401)
关键词
癌
鳞状细胞
腺癌
诊断
鉴别
C4.4A
Carcinoma, squamous cell
Adenocarcinoma
Diagnosis,differential
CA. 4A
